1127-41-9Relevant articles and documents
New (α-hydroxyalkyl)phosphorus amphiphiles: Synthesis and dissociation constants
Albouy, Dominique,Brun, Alice,Munoz, Aurelio,Etemad-Moghadam, Guita
, p. 7223 - 7230 (1998)
Direct synthesis of free (α-hydroxyalkyl)phosphinic acid amphiphiles 1 can be readily realized by sonication of the heterogeneous mixture of 50% aqueous hypophosphorous acid and long-chain aldehydes in the presence of catalytic amounts of hydrochloric aci
Direct Approach to α-Hydroxyphosphonic and α,ω-Dihydroxyalkane-α,ω-bisphosphonic Acids by the Reduction of (Bis)acylphosphonic Acids
Chen, Ravit,Breuer, Eli
, p. 5107 - 5109 (1998)
Acylphosphonic and bisacylphosphonic acid sodium salts were directly reduced by sodium borohydride to the corresponding hydroxyphosphonates and dihydroxyalkanebisphosphonates. The solution conformation of the (bis)hydroxyphosphonic acid sodium salts, eluc
Silyl Phosphite Equivalents: 2,2,2-Trichloroethoxycarbonylphosphonates
Sekine, Mitsuo,Yamagata, Hiraku,Hata, Tsujiaki
, p. 970 - 971 (1981)
2,2,2-Trichloroethoxycarbonylphosphonates were converted directly by treatment with Zn-Me3SiCl into silyl phosphites which in situ reacted with aldehydes to give α-hydroxyphosphonates in good yields.
Optimization and a Kinetic Study on the Acidic Hydrolysis of Dialkyl α-Hydroxybenzylphosphonates
Harsági, Nikoletta,Rádai, Zita,Szigetvári, áron,Kóti, János,Keglevich, Gy?rgy
, (2020/09/04)
The two-step acidic hydrolysis of α-hydroxybenzylphosphonates and a few related derivatives was monitored in order to determine the kinetics and to map the reactivity of the differently substituted phosphonates in hydrolysis. Electron-withdrawing substituents increased the rate, while electron-releasing ones slowed down the reaction. Both hydrolysis steps were characterized by pseudo-first-order rate constants. The fission of the second P-O-C bond was found to be the rate-determining step.
Green synthesis and cytotoxic activity of dibenzyl α-hydroxyphosphonates and α-hydroxyphosphonic acids
Rádai, Zita,Szeles, Petra,Kiss, Nóra Zsuzsa,Heged?s, László,Windt, Tímea,Nagy, Veronika,Keglevich, Gy?rgy
, (2018/09/25)
A series of dibenzyl α-hydroxyphosphonates and the corresponding α-hydroxyphosphonic acids, mostly new compounds, have been synthesized. The dibenzyl α-hydroxyphosphonates have been obtained in the Pudovik reaction of substituted benzaldehydes and dibenzyl phosphite in the presence of triethylamine as the catalyst. The amount of the solvent was minimized during the reaction, and the workup involved crystallization from the reaction mixture. A new protocol was developed to transform the dibenzyl 1-hydroxyphosphonates to the corresponding phosphonic acids by catalytic hydrogenation. The derivatives prepared were screened as potential cytotoxic agents against Mes-Sa human uterine sarcoma cell line.
