112849-26-0 Usage
Description
(5E,24R)-1,3-Bis-O-(tert-ButyldiMethylsilyl)-calcipotriene is a derivative of (5E)-Calcipotriene (C144210), which is a biologically active vitamin D3 analogue. It is characterized by its clear oil chemical property and serves as an intermediate in the preparation of MC 903.
Uses
Used in Pharmaceutical Industry:
(5E,24R)-1,3-Bis-O-(tert-ButyldiMethylsilyl)-calcipotriene is used as an intermediate in the synthesis of MC 903, a biologically active vitamin D3 analogue. (5E,24R)-1,3-Bis-O-(tert-ButyldiMethylsilyl)-calcipotriene plays a crucial role in the development of pharmaceuticals targeting various health conditions, given the therapeutic potential of vitamin D3 analogues.
Used in Research and Development:
In the field of research and development, (5E,24R)-1,3-Bis-O-(tert-ButyldiMethylsilyl)-calcipotriene is utilized for studying the properties and effects of vitamin D3 analogues. This helps scientists and researchers to understand their mechanisms of action and potential applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 112849-26-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,4 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 112849-26:
(8*1)+(7*1)+(6*2)+(5*8)+(4*4)+(3*9)+(2*2)+(1*6)=120
120 % 10 = 0
So 112849-26-0 is a valid CAS Registry Number.
112849-26-0Relevant articles and documents
EPIMERIZATION BY STEREOSELECTIVE SYNTHESIS OF VITAMIN D ANALOGUES
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Page/Page column 10-11, (2009/06/27)
A method for epimerization process of C-24 ketones to desired C-24 alcohol by stereo selective reduction using chiral borane reducing agents in the presence of chiral auxillary such as (R)-2-methyl-CBS-oxazaborolidine for the preparation of calcipotriene intermedites and its process to calcipotriene.
STEREOSELECTIVE SYNTHESIS OF VITAMIN D ANALOGUES
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Page/Page column 29-30, (2008/06/13)
The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.
Synthesis of MC 903, a biologically active vitamin D metabolite analogue
Calverley
, p. 4609 - 4619,4609-4619 (2007/10/02)
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