7691-76-1

Basic information

• Product Name: 1-Cyclopropyl-2-(triphenylphosphoranylidene)-ethanone
• Synonyms: 1-Cyclopropyl-2-(triphenylphosphoranylidene)-ethanone;[(Cyclopropylcarbonyl)methylene]triphenylphosporane;1-Cyclopropyl-2-(triphenylphosphoranylidene)ethan-1-one;Cyclopropylcarbonylmethylenetriphenylphosphorane
• CAS NO: 7691-76-1
• Molecular Formula: C₂₃H₂₁OP
• Molecular Weight: 344.386001
• Product Categories: Miscellaneous Reagents
• Mol File: 7691-76-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 511.5±33.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 1-Cyclopropyl-2-(triphenylphosphoranylidene)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-2-(triphenylphosphoranylidene)-ethanone(7691-76-1)
• EPA Substance Registry System: 1-Cyclopropyl-2-(triphenylphosphoranylidene)-ethanone(7691-76-1)

Safety Data

• Hazardous Substances Data: 7691-76-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 54454-39-6 Triphenyl-{1-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-cyclopropyl}-phosphonium; bromide 
• 112849-15-7 (2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide 
• 765-43-5 Cyclopropyl methyl ketone 
• 603-35-0 triphenylphosphine 
• 69267-75-0 2-bromo-1-cyclopropylethan-1-one 

Downstream Products

• 63261-41-6 (E)-1-cyclopropyl-3-phenylpropen-1-one 
• 112849-18-0 20(R),3(R)-(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxoprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112849-17-9 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl-1’(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 115648-68-5 (1S,3R,20S)-bis(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 112849-24-8 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'ξ-cyclopropyl-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 112849-23-7 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 112827-99-3 20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112965-21-6 calcipotriene 
• 112910-41-5 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(R)-cycloprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112849-26-0 (1S,3R,3'R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 112875-61-3 (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10⁽¹⁹⁾-triene 
• 112849-27-1 (1S,3R,3'S)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115540-29-9 (1S,3R,1'S,2'S,3'R)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 
• 115540-29-9 (1S,3R,1'S,2'S,3'S)-(3'-cyclopropyl-1',2'-epoxy-3'-hydroxypropyl)-9,10-secopregna-5(E),7(E),10⁽¹⁹⁾-triene 

Relevant articles and documents

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

Method for preparing cyclopropyl carbonyl methylene triphenyl phosphine

The invention relates to a method for preparing cyclopropyl carbonyl methylene triphenyl phosphine. The method comprises the following steps: (1) enabling cyclopropyl methyl ketone to react with bromine so as to obtain cyclopropyl bromomethyl ketone; (2) enabling the cyclopropyl bromomethyl ketone to react with triphenyl phosphine so as to obtain brominized triphenyl phosphine cyclopropyl carbonylmethyl; and (3) enabling the brominized triphenyl phosphine cyclopropyl carbonyl methyl to react with sodium hydroxide, thereby obtaining cyclopropyl carbonyl methylene triphenyl phosphine. The content of a cyclopropyl carbonyl methylene triphenyl phosphine product prepared by using the method provided by the invention is up to 98.4% or above, the product quality is good, and the defect that a product prepared by using a conventional preparation method is low in content is overcome. In addition, the preparation method provided by the invention is simple to operate, simple in step, easy in product impurity separation and removal, and beneficial to large-scale industrial production.

PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS

This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.