113577-68-7

Basic information

• Product Name: Pyridine, 2-(2-methoxyphenyl)-6-methyl-
• CAS NO: 113577-68-7
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol File: 113577-68-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(2-methoxyphenyl)-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(2-methoxyphenyl)-6-methyl-(113577-68-7)
• EPA Substance Registry System: Pyridine, 2-(2-methoxyphenyl)-6-methyl-(113577-68-7)

Safety Data

• Hazardous Substances Data: 113577-68-7(Hazardous Substances Data)

Upstream product

• 5315-25-3 2-bromo-6-methylpyridine 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 67-56-1 methanol 
• 18368-63-3 6-chloro-2-picoline 

Downstream Products

• 201607-63-8 2-(2-hydroxyphenyl)-6-methylpyridine 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF

Provided are a nitrogenous heterocyclic aromatic compound, a preparation method therefor, a pharmaceutical composition thereof, and an application thereof. The nitrogenous heterocyclic aromatic compound can be used for treating and/or preventing various diseases mediated by ALK5.

Copper-catalyzed fluorination of 2-pyridyl aryl bromides

Copper(i)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using AgF as the fluorine source. In this transformation a pyridyl directing group is essential for successful catalytic fluorination. A XANES/EXAFS study indicated that the presence of the pyridyl group is essential to stabilize the Cu(i) species and accelerate oxidative addition of the aryl bromide. Further mechanistic studies implicated a Cu(i/iii) catalytic cycle in this Cu(i)-catalyzed fluorination, and final aryl C-F bond formation possibly proceeds through an irreversible reductive elimination of the ArCu(iii)-F species. This rare report of catalytic fluorination by a copper catalyst provides a valuable foundation for further development of Cu(i)-catalyzed fluorination of aryl halides.

The palladium catalysed Suzuki coupling of 2- and 4-chloropyridines

The Suzuki coupling of 2- and 4-chloropyridines with arylboronic acids is successfully performed under Pd(PPh3)4 catalysis. Moderate to good yields are obtained with 4-chloropyridines while 2-chloropyridines give excellent yields. The corresponding pyridine N-oxides react in the same manner. An easy and cheap access to arylpyridines, a class of compound with medicinal interest, is thus achieved.