18368-63-3 Usage
Description
6-Chloro-2-picoline, a derivative of picoline, is an organic compound characterized by its light yellow liquid appearance. It is a heterocyclic compound with a chlorine atom at the 6th position and a methyl group at the 2nd position on the pyridine ring. This unique structure endows it with specific chemical properties that make it suitable for various applications across different industries.
Uses
Used in Chemical Synthesis:
6-Chloro-2-picoline is used as a key intermediate in the synthesis of various organic compounds, particularly those with pharmaceutical and agrochemical applications. Its reactivity and functional group compatibility make it a valuable building block for creating complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Chloro-2-picoline is utilized as a starting material for the development of new drugs. Its unique chemical structure allows for the creation of novel therapeutic agents that can target specific biological pathways.
Used in Agrochemical Industry:
6-Chloro-2-picoline is also employed in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its chemical properties enable the development of compounds that can effectively control pests and diseases in agriculture.
Used in Analytical Chemistry:
6-Chloro-2-picoline finds application in analytical chemistry as a reagent or a reference compound in experimental techniques such as Fourier-transform infrared (FTIR) and Fourier-transform Raman (FT-Raman) spectroscopic analyses. Its distinct spectral features make it useful for conformational studies and the identification of molecular structures.
Check Digit Verification of cas no
The CAS Registry Mumber 18368-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,6 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18368-63:
(7*1)+(6*8)+(5*3)+(4*6)+(3*8)+(2*6)+(1*3)=133
133 % 10 = 3
So 18368-63-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
18368-63-3Relevant articles and documents
Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 5565 - 5570 (2019/10/22)
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.
Unusual C-6 lithiation of 2-chloropyridine-mediated by BuLi-Me2N(CH2)2OLi. New access to 6-functional-2-chloropyridines and chloro-bis-heterocycles
Choppin, Sabine,Gros, Philippe,Fort, Yves
, p. 803 - 805 (2007/10/03)
Formula Presented The reaction of 2-chloropyridine with alkylithium generally results in nucleophilic addition leading to the loss of chlorine atom while exclusive directed ortho metalation is obtained using LDA. Herein it is shown that the BuLi-Me2
Pyridylthio-acylanilide herbicides
-
, (2008/06/13)
Novel herbicidally active pyridylthio-acylanilides of the formula STR1 in which R1, R2 and R3, independently of one another, represent hydrogen, halogen, cyano or trifluoromethyl or alkyl, alkoxy and alkylthio having 1 to 4 carbon atoms in each case, R4 represents halogen, methyl or methoxy, n represents a number 0, 1 or 2, z represents the group (Ia) STR2 or the group (Ib) STR3 where X represents oxygen, sulphur, an N--R10 or N--O--R11 group, or X and Rg tpgether represent the STR4 radical, and the other radicals can have various meanings. Intermediates of the formulae STR5 are also new.
