63763-79-1Relevant articles and documents
Tuning the conversion of cyclohexane into cyclohexanol/one by molecular dioxygen, protons and reducing agents at a single non-porphyrinic iron centre and chemical versatility of the tris(2-pyridylmethyl)amine TPAFe IICl2 complex in mild oxidation chemistry
Jaafar, Hassen,Vileno, Bertrand,Thibon, Aurore,Mandon, Dominique
, p. 92 - 106 (2011)
We report that the oxygen sensitivity of some Fe(ii) complexes with tripodal ligands can be used, with benefit, in the oxidation of cyclohexane under mild conditions. Depending on the solvent, two very different reaction pathways are involved, which share the coordination of O2 to the metal as the common initial step. We have synthesized a series of α-chlorinated tripods in the tris(2-pyridylmethyl)amine series Cl nTPA (n = 1-3) and fully characterized the corresponding FeX 2 complexes (X = Cl, CF3SO3). The single-crystal X-ray structure analyses of the FeCl2 complexes are reported. In CH3CN, the FeCl2 complexes react smoothly with O2, whereas the Fe(CF3SO3)2 complexes are non-sensitive. In CH3CN, the reaction of the oxygen-sensitive ClnTPAFeCl2 (n = 0-3) with O2, acetic acid and zinc amalgam, in the presence of cyclohexane, affords a mixture of cyclohexanol/one in an ≈ ol/one ratio of 3.1 and a selectivity of the C3°/C2° in the adamantane conversion that is consistent with a metal-oxo based oxidation. Limited efficiency (≈ 2 TON) was observed for the parent TPAFeCl2 complex and Cl1TPAFeCl2, whereas both other complexes turned out to be poorly active. The TPAFeCl2 complex was used to address mechanistic questions: when the reaction was carried out in pyridine, the ol/one ratio shifted to 0.15 while efficiency was improved by 7-fold. In pyridine and in the presence of a spin trap (DMPO), the radical-based character of the reaction was definitely established, by contrast with acetonitrile, where no oxygenated radicals were detected. Thus, the reactivity differences arise from involvement of two distinct active species. The dichotomous radical/biomimetic pathway is discussed to interpret these results.
4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS
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Page/Page column 94, (2011/10/10)
The present invention relates to novel compounds for use in the compositions, to processes for their preparation, to intermediates useful in their preparation and to their use as therapeutic agents. The present invention also relates to pharmaceutical com
ANTIVIRAL PHOSPHINATE COMPOUNDS
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Page/Page column 192-193, (2008/06/13)
The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.