28369-92-8

Basic information

• Product Name: Pyridine, 2-methyl-6-phenoxy-
• CAS NO: 28369-92-8
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol File: 28369-92-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-methyl-6-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-methyl-6-phenoxy-(28369-92-8)
• EPA Substance Registry System: Pyridine, 2-methyl-6-phenoxy-(28369-92-8)

Safety Data

• Hazardous Substances Data: 28369-92-8(Hazardous Substances Data)

Upstream product

• 18368-63-3 6-chloro-2-picoline 
• 108-95-2 phenol 
• 100-67-4 potassium phenolate 
• 281221-71-4 6-methylpyridine-2-sulfonyl chloride 
• 3279-76-3 6-methyl-2(1H)-pyridone 
• 3279-76-3 6-hydroxy-2-methylpyridine 
• 5315-25-3 2-bromo-6-methylpyridine 
• 118-92-3 anthranilic acid 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 

Downstream Products

• 77510-99-7 (6-phenoxy-2-pyridyl) methyl 4-(4-fluorophenyl)-2-isopropyl-3-butenoate 
• 28369-98-4 2-(2,6-dichlorophenoxy)-6-methylpyridine 
• 75390-46-4 6-phenoxy-2-picoline-N-oxide 

Relevant articles and documents

Ruthenium-Catalyzed meta-CAr–H Bond Difluoroalkylation of 2-Phenoxypyridines

A ruthenium-catalyzed meta-selective CAr–H bond difluoroalkylation of 2-phenoxypyridine using 2-bromo-2,2-difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2-(meta-difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.

PRODUCTION METHOD FOR BI(HETERO)ARYL(THIO)ETHER COMPOUND

PROBLEM TO BE SOLVED: To provide a method for synthesizing a bi(hetero)aryl(thio)ether compound at low cost without discharging halogen-derived waste. SOLUTION: The production method includes, for example as shown in the following formula, reacting a (thio)ester compound represented by formula (1) in the presence of a nickel catalyst (or a palladium catalyst) as well as a ligand compound to produce bi(hetero)aryl(thio)ether compound represented by formula (2). [Ar and Ar' are each independently a substituted/unsubstituted aryl group or heteroaryl group; Y is O or S.]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT