120145-29-1Relevant articles and documents
6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents
Pavia,Taylor,Lobbestael
, p. 1237 - 1242 (2007/10/02)
The anticonvulsant effect of a series of 6-alkyl-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the anticonvulsant activity and reduce behavioral side effects in this series. Three compounds (7, 8, 10; Table I) were selected from initial screening for a more complete pharmacological evaluation. While each of these compounds was a potent anticonvulsant agent with ED50 values from 5 to 10 mg/kg, the activity was accompanied by significant behavioral side effects including decreased spontaneous locomotion, ataxia, and ptosis.
