1146160-52-2

Basic information

• Product Name: tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate
• Synonyms: tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate
• CAS NO: 1146160-52-2
• Molecular Weight: 491.59
• Mol File: 1146160-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate(1146160-52-2)
• EPA Substance Registry System: tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate(1146160-52-2)

Safety Data

• Hazardous Substances Data: 1146160-52-2(Hazardous Substances Data)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 254881-77-1 1-tert-butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate 
• 108240-11-5 4-chloro-2-(2-methoxyphenyl)quinazoline 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 1028-96-2 2-(2-methoxyphenyl)quinazolin-4-ol 
• 708289-25-2 C₁₅H₁₂N₂O₂ 
• 1146160-48-6 1-tert-butyl 2-methyl (2R,4S)-4-((2-(2-methoxyphenyl)quinazolin-4-yl)amino)pyrrolidine-1,2-dicarboxylate 
• 1146160-50-0 (2R,4S)-1-(tert-butoxycarbonyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-2-carboxylic acid 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 1146160-53-3 (2R,4S)-4-(2-(2-hydroxyphenyl)quinazolin-4-ylamino)-N,N-dimethylpyrrolidine-2-carboxamide 

Relevant articles and documents

Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2

Structure-based design was applied to the optimization of a series of 2-(quinazolin-2-yl)phenols to generate potent and selective ATP-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2). Structure-activity relationships for multiple substituent positions were optimized separately and in combination leading to the 2-(quinazolin-2-yl) phenol 46 (IC50 3 nM) with good selectivity for CHK2 against CHK1 and a wider panel of kinases and with promising in vitro ADMET properties. Off-target activity at hERG ion channels shown by the core scaffold was successfully reduced by the addition of peripheral polar substitution. In addition to showing mechanistic inhibition of CHK2 in HT29 human colon cancer cells, a concentration dependent radioprotective effect in mouse thymocytes was demonstrated for the potent inhibitor 46 (CCT241533).