254881-77-1

Basic information

• Product Name: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
• Synonyms: (2R,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester;Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected;1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinedicarboxylate;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinecarboxylate;(2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl;Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-aMinopyrrolidine-2-carboxylate;Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected, trans-4-Amino-D-proline methyl ester, N1-BOC protected, (2R,4S)-4-amino-1-(tert-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine
• CAS NO: 254881-77-1
• Molecular Formula: C₁₁H₂₀N₂O₄
• Molecular Weight: 244.29
• Mol File: 254881-77-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321 °C
• Flash Point: 148 °C
• Appearance: /
• Density: 1.151
• Refractive Index: 1.507
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.05±0.40(Predicted)
• CAS DataBase Reference: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate(254881-77-1)
• EPA Substance Registry System: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate(254881-77-1)

Safety Data

• Hazardous Substances Data: 254881-77-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H20N2O4/c1-10(2,3)17-9(16)13-6-7(12)5-11(13,4)8(14)15/h7H,5-6,12H2,1-4H3,(H,14,15)/t7-,11+/m0/s1

Upstream product

• 185304-04-5 (2R,4S)-1-tert-butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 148017-26-9 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(R)-methanesulfonylpyrrolidine 
• 135042-09-0 (2R,4R)-N^α-(tert-butoxycarbonyl)-4-(p-toluenesulfonyloxy)proline methyl ester 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 

Downstream Products

• 317860-13-2 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(pyrrolidin-1N-yl)pyrrolidine 
• 1055034-49-5 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-chlorosulfonamido)pyrrolidine 
• 317860-17-6 1N-tert-butoxycarbonyl-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine 
• 317860-15-4 1N-(4-phenoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(pyrrolidin-1N-yl)pyrrolidine 
• 317860-19-8 1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine 
• 1053631-96-1 (3'S,5'R)-1'-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-[1,3']bipyrrolidinyl-5'-carboxylic acid methyl ester 
• 1054625-30-7 (2R,4S)-1-(4-Butoxy-benzenesulfonyl)-4-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)-pyrrolidine-2-carboxylic acid methyl ester 
• 1146160-48-6 1-tert-butyl 2-methyl (2R,4S)-4-((2-(2-methoxyphenyl)quinazolin-4-yl)amino)pyrrolidine-1,2-dicarboxylate 
• 1226771-75-0 methyl (2R,4S)-1-Boc-4-[(4,4-dimethylcyclohexyl)amino]pyrrolidine-2-carboxylate 
• 1146161-62-7 1-tert-butyl 2-methyl (2R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1,2-dicarboxylate 
• 1146160-50-0 (2R,4S)-1-(tert-butoxycarbonyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-2-carboxylic acid 
• 1146160-52-2 tert-butyl (2R,4S)-2-(dimethylcarbamoyl)-4-(2-(2-methoxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate 
• 1146161-64-9 4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol 

Relevant articles and documents

Divergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3-Amidocyclohexanones

Phosphothreonine (pThr)-embedded peptide catalysts are found to mediate the reductive amination of 3-amidocyclohexanones with divergent selectivity. The choice of peptide sequence can be used to alter the diastereoselectivity to favor either the cis-product or trans-product, which are obtained in up to 93:7 er. NMR studies and DFT calculations are reported and indicate that both pathways rely on secondary interactions between substrate and catalyst to achieve selectivity. Furthermore, catalysts appear to accomplish a parallel kinetic resolution of the substrates. The facility for phosphopeptides to tune reactivity and access multiple products in reductive aminations may translate to the diversification of complex substrates, such as natural products, at numerous reactive sites.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound having a good agonistic activity to melanocortin receptor, or pharmaceutically acceptable salt or isomer thereof, and an agonistic composition for melanocortin receptor comprising the same as an active ingredient.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.