115093-90-8

Basic information

• Product Name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine;5-Chloro-4-chloro-7H-pyrrolo[2,3-d]pyrimidine;5-Chloro-4-chloro-7H-pyrr...
• CAS NO: 115093-90-8
• Molecular Formula: C₆H₃Cl₂N₃
• Molecular Weight: 188.01
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 115093-90-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 290 °C
• Boiling Point: 361.101 °C at 760 mmHg
• Flash Point: 203.556 °C
• Appearance: /
• Density: 1.675 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.724
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.52±0.20(Predicted)
• CAS DataBase Reference: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(115093-90-8)
• EPA Substance Registry System: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine(115093-90-8)

Safety Data

• Hazardous Substances Data: 115093-90-8(Hazardous Substances Data)

Usage

General Description

4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a chemical compound with the molecular formula C6H3Cl2N3. It is a heterocyclic compound with a fused pyrrole and pyrimidine ring system. 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is used as a building block in the synthesis of pharmaceutical drugs and agrochemicals. It has been studied for its potential anti-cancer properties and is used in research for the development of new drugs. Additionally, it is also used as a reagent in organic synthesis and as a precursor in the manufacturing of other chemical compounds.

InChI:InChI=1/C6H3Cl2N3/c7-3-1-9-6-4(3)5(8)10-2-11-6/h1-2H,(H,9,10,11)

Upstream product

• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1618-36-6 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 123148-80-1 7-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 157666-30-3 4,5-dichloro-7-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 952429-08-2 4,5-dichloro-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 952429-09-3 4,5-dichloro-7-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1041703-73-4 C₁₄H₁₀ClN₇ 
• 908283-43-2 C₂₆H₂₄ClN₅O₂ 
• 1192189-19-7 1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide 
• 1365626-36-3 C₂₂H₂₂ClN₅OS 
• 1380310-92-8 C₁₃H₉Cl₂N₃ 
• 1372611-11-4 4,5-dichloro-7-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1383342-15-1 N-[1-(5-chloro-1H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide 
• 1383343-42-7 N-{1-[5-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}benzamide 
• 1613479-25-6 C₁₂H₆ClF₂N₃O 

Relevant articles and documents

Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin

Modified carbocyclic nucleosides (4a-g) constituting 7-deazapurine, 4′-methyl, exocyclic double bond and 2′,3′-hydroxy were synthesized. NOE and X-ray studies of4cconfirmed the α-configuration of 4′-methyl. The anti-HBV assay demonstrated4e(IC50/sub

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

ASK1 INHIBITING PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES

The present invention relates to pyrrolopyrimidine compounds according to Formula (I) and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. (Formula (I))