1618-36-6Relevant articles and documents
Tetrahydropyrrolopyrazoles derivatives Preparation method and application thereof in medicine
-
Paragraph 0342-0348, (2021/09/29)
The invention relates to tetrahydropyrrolopyrazol derivatives, a preparation method and an application thereof in medicine. , The present disclosure relates to a tetrahydropyrrolopyrazol derivative represented by the general formula (I), a preparation method thereof, and a use of the derivative-containing pharmaceutical composition and as a therapeutic agent, in particular as AKT1 T1 T1 T1 AKT pan T1 inhibitors and use thereof in the preparation of a medicament for the treatment and/or prevention of tumors.
ASK1 INHIBITING PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES
-
Paragraph 0154, (2019/02/02)
The present invention relates to pyrrolopyrimidine compounds according to Formula (I) and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. (Formula (I))
Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists
Hu, Yun-Jin,St.-Onge, Miguel,Laliberté, Sébastien,Vallée, Frédéric,Jin, Shujuan,Bedard, Leanne,Labrecque, Jean,Albert, Jeffrey S.
supporting information, p. 3199 - 3203 (2015/02/19)
A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.