1160527-68-3

Basic information

• Product Name: pentafluorophenyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate
• Synonyms: pentafluorophenyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate
• CAS NO: 1160527-68-3
• Molecular Weight: 445.434
• Mol File: 1160527-68-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: pentafluorophenyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: pentafluorophenyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate(1160527-68-3)
• EPA Substance Registry System: pentafluorophenyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate(1160527-68-3)

Safety Data

• Hazardous Substances Data: 1160527-68-3(Hazardous Substances Data)

Upstream product

• 14533-84-7 pentafluorophenyl trifloroacetate 
• 201611-92-9 4-cyano-4-(thiobenzoylthio)pentanoic acid 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 5873-93-8 bis(thiobenzoyl) disulfide 
• 2638-94-0 4,4'-dicyano-4,4'-azo-di-valeric acid 

Downstream Products

• 1212057-35-6 N-biotinyl-N′-(3-(4-phenylthiocarbonylthio-4-cyanovaleryl)-3,6-dioxaoctane-1,8-diamine) 
• 1146697-76-8 C₂₁H₂₂N₂O₃S₂ 

Relevant articles and documents

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation

Fast and bioorthogonally reacting nanoparticles are attractive tools for biomedical applications such as tumor pretargeting. In this study, we designed an amphiphilic block copolymer system based on HPMA using different strategies to introduce the highly reactive click units 1,2,4,5-tetrazines (Tz) either at the chain end (Tz-CTA) or statistical into the hydrophobic block. This reactive group undergoes a rapid, bioorthogonal inverse electron-demand Diels-Alder reaction (iEDDA) with trans-cyclooctenes (TCO). Subsequently, this polymer platform was used for the preparation of different Tz-covered nanoparticles, such as micelles and colloids. Thereby it was found that the reactivity of the polymeric micelles is comparable to that of the low molar mass tetrazines. The core-cross-linked micelles can be successfully conjugated at rather low concentrations to large biomacromolecules like antibodies, not only in physiological buffer, but also in human blood plasma, which was confirmed by fluorescence correlation spectroscopy (FCS).

HPMA-Based Nanocarriers for Effective Immune System Stimulation

The selective activation of the immune system using nanoparticles as a drug delivery system is a promising field in cancer therapy. Block copolymers from HPMA and laurylmethacrylate-co-hymecromone-methacrylate allow the preparation of multifunctionalized

DNA-Polymer Conjugates by Photoinduced RAFT Polymerization

Conventional grafting-to approaches to DNA-polymer conjugates are often limited by low reaction yields due to the sterically hindered coupling of a presynthesized polymer to DNA. The grafting-from strategy, in contrast, allows one to directly graft polymers from an initiator that is covalently attached to DNA. Herein, we report blue-light-mediated reversible addition-fragmentation chain-transfer (Photo-RAFT) polymerization from two different RAFT agent-terminated DNA sequences using Eosin Y as the photocatalyst in combination with ascorbic acid. Three monomer families (methacrylates, acrylates and acrylamides) were successfully polymerized from DNA employing Photo-RAFT polymerization. We demonstrate that the length of the grown polymer chain can be varied by altering the monomer to DNA-initiator ratio, while the self-assembly features of the DNA strands were maintained. In summary, we describe a convenient, light-mediated approach toward DNA-polymer conjugates via the grafting-from approach.