201611-92-9Relevant articles and documents
Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging
Yang, Shun,Li, Najun,Chen, Dongyun,Qi, Xiuxiu,Xu, Yujie,Xu, Ying,Xu, Qingfeng,Li, Hua,Lu, Jianmei
, p. 4628 - 4636 (2013)
A core-shell nanocomposite based on photo-degradable polymer coated hollow mesoporous silica nanoparticles (HMS) was successfully prepared for targeted drug delivery and visible-light triggered release, as well as fluorescence cell imaging. The HMS nanoparticles were first modified by the long-chain hydrocarbon octadecyltrimethoxysilane (C18) and fluorescent agent Rhodamine B isothiocyanate (RITC), and then encapsulated by a photodegradable amphiphilic copolymer via a self-assembly process. The obtained nanocarrier showed a high drug loading content due to the hollow core and mesopores of the HMS and could target folic acid receptor over-expressed tumor cells efficiently for conjugating folic acid (FA) in the amphiphilic polymer. The drug release could be triggered by the irradiation of green light (500-540 nm) due to the photodegradation of amphiphilic copolymer coated on the HMS. Furthermore, the targeted drug delivery and controlled release processes could be tracked by fluorescence imaging for the doping of RITC on the HMS. The In vitro results suggested that a smart visible light responsive drug delivery system was successfully prepared for the potential applications of cancer diagnosis and therapy.
Fine-tuning the transition temperature of a stimuli-responsive polymer by a simple blending procedure
Fernandez-Trillo, Francisco,Van Hest, Jan C. M.,Thies, Jens C.,Michon, Thierry,Weberskirch, Ralf,Cameron, Neil R.
, p. 2230 - 2232 (2008)
Binary mixtures of well-defined, stimuli-responsive elastin-based side-chain polymers show a single transition temperature that depends on blend composition. The Royal Society of Chemistry.
Visible-Light-Driven MADIX Polymerisation via a Reusable, Low-Cost, and Non-Toxic Bismuth Oxide Photocatalyst
Hakobyan, Karen,Gegenhuber, Thomas,McErlean, Christopher S. P.,Müllner, Markus
supporting information, p. 1828 - 1832 (2019/01/14)
The continuous amalgamation of photocatalysis into existing reversible deactivation radical polymerisation (RDRP) processes has initiated a rapidly propagating area of polymer research in recent years. We introduce bismuth oxide (Bi2O3) as a heterogeneous photocatalyst for polymerisations, operating at room temperature with visible light. We demonstrate formidable control over degenerative chain-transfer polymerisations, such as macromolecular design by interchange of xanthate (MADIX) and reversible addition-fragmentation chain-transfer (RAFT) polymerisation. We achieved narrow molecular weight distributions and attribute the excellent temporal control of a photo-induced electron transfer (PET) process. This methodology was employed to synthesise diblock copolymers combining differently activated monomers. The Bi2O3 catalyst system has the additional benefits of low toxicity, reusability, low-cost, and ease of removal from the reaction mixture.
A new selenium-based RAFT agent for surface-initiated RAFT polymerization of 4-vinylpyridine
Demirci, Serkan,Kinali-Demirci, Selin,Caykara, Tuncer
, p. 5345 - 5350 (2013/09/23)
A new selenium-based reversible addition-fragmentation chain transfer (RAFT) agent, 4-cyanopentanoic acid diselenobenzoate (RAFT-Se), was synthesized and utilized in the surface-initiated RAFT polymerization of 4-vinylpyridine (4VP) on silicon substrate. The results indicate that the RAFT-Se can control the surface-initiated RAFT polymerization, as evidenced by the number-average molecular weight that increase linearly with monomer conversion, molecular weights that agreed well with the predicted values, and the relatively low polydispersity indexes. The surface-initiated RAFT polymerization with the RAFT-Se was the same polymerization mechanism as its analog, 4-cyanopentanoic acid dithiobenzoate (RAFT-S). The grafting density of the poly(4-vinylpyridine) brushes prepared in the presence of RAFT-Se (σRAFT-Se) and RAFT-S (σRAFT-S) was estimated to be about 0.51 and 0.66 chains/nm2, respectively. In addition, the end of polymer chains on silicon substrate contains selenium element which may be useful in biosensor applications.
