851961-99-4 Usage
Description
2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol, also known as (2-pyridyldithio)-PEG2-alcohol, is a PEG linker that contains a pyridyl disulfide moiety and an alcohol group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH levels, while the hydroxyl group allows for further derivatization of the compound. The hydrophilic PEG linker increases the water solubility of the compound, making it a versatile molecule for various applications.
Uses
Used in Bioconjugation Applications:
2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol is used as a bioconjugation agent for the selective attachment of proteins, peptides, and other biomolecules. The pyridyl disulfide group forms stable linkages with thiol groups, enabling the formation of well-defined bioconjugates with minimal disruption to the biological activity of the attached molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG linker enhances the hydrophilicity of the drug, reducing aggregation and increasing circulation time in the body, while the pyridyl disulfide group allows for targeted delivery to specific cells or tissues.
Used in Analytical Chemistry:
2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol is used as a reagent in analytical chemistry for the detection and quantification of thiol-containing compounds. The selective reaction between the pyridyl disulfide group and thiol groups allows for the specific labeling and separation of target molecules in complex samples.
Used in Materials Science:
In materials science, 2-(2-(2-(2-(pyridin-2-yldisulfanyl)ethoxy)ethoxy)ethoxy)ethan-1-ol is used as a building block for the development of functional polymers and materials with tailored properties. The pyridyl disulfide group can be used to create reversible cross-links or to attach functional groups to polymer chains, while the PEG linker provides enhanced solubility and stability.
Check Digit Verification of cas no
The CAS Registry Mumber 851961-99-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,9,6 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 851961-99:
(8*8)+(7*5)+(6*1)+(5*9)+(4*6)+(3*1)+(2*9)+(1*9)=204
204 % 10 = 4
So 851961-99-4 is a valid CAS Registry Number.
851961-99-4Relevant articles and documents
COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE
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Paragraph 0328, (2019/01/08)
Several embodiments provided in the present disclosure relate to compositions that carry an antigen to which tolerance is desired, the antigen being coupled, bound, or otherwise joined to a targeting moiety, the targeting moiety configured to direct the composition to the liver of a subject. In several embodiments, the antigen in coupled to the targeting moiety by way of a polymeric linker. In several embodiments, the polymeric linker is configured to liberate the antigen in vivo. Methods of using the compositions to reduce and/or prevent unwanted immune responses against an antigen of interest are also provided.
