117445-22-4 Usage
Description
Boc-3-Aminomethylbenzoic acid, also known as 3-(Boc-aminomethyl)benzoic acid, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its off-white powder form and is used in the development of drugs targeting specific enzymes and receptors.
Uses
Used in Pharmaceutical Industry:
Boc-3-Aminomethylbenzoic acid is used as a synthetic intermediate for the development of aminodihydroquinazolines, which are inhibitors of BACE-1 (β-site APP cleaving enzyme). These inhibitors play a crucial role in the treatment of neurodegenerative diseases, such as Alzheimer's, by reducing the formation of amyloid-beta peptides.
Additionally, Boc-3-Aminomethylbenzoic acid is used as a synthetic precursor in the preparation of spiro[1H-indene-1,4''-piperidine] derivatives. These derivatives are potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists, which have potential applications in the treatment of various disorders, including neuroendocrine tumors and diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 117445-22-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,4,4 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 117445-22:
(8*1)+(7*1)+(6*7)+(5*4)+(4*4)+(3*5)+(2*2)+(1*2)=114
114 % 10 = 4
So 117445-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4/c1-13(2,3)18-12(17)10-8(7-14)5-4-6-9(10)11(15)16/h4-6H,7,14H2,1-3H3,(H,15,16)
117445-22-4Relevant articles and documents
Design, synthesis and biological evaluation of 4′-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors
Zhang, Xuan,Zhang, Jie,Su, Mingbo,Zhou, Yubo,Chen, Yi,Li, Jia,Lu, Wei
, p. 40444 - 40448 (2014/12/11)
A new class of 4′-demethyl-4-deoxypodophyllotoxin derivatives has been designed and synthesized as tubulin-HDAC dual inhibitors. Biological evaluation of these hybrids included the inhibitory activity of HDAC, in vitro cell cycle analysis in HCT-116 cells as well as cytotoxicity against two cancer cell lines (A549 and HCT116). The distance and angle between the HDAC capping group and the zinc binding group were systematically varied. Compounds 14a and 14c showed most potent dual inhibitory activity and powerful antiproliferative activity on HCT116 and A549 cell lines. This journal is
HISTONE DEACETYLASE INHIBITORS
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, (2011/04/13)
The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.
Spiro [1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists [1]
Yang, Lihu,Guo, Liangqin,Pasternak, Alexander,Mosley, Ralph,Rohrer, Susan,Birzin, Elizabeth,Foor, Forrest,Cheng, Kang,Schaeffer, James,Patchett, Arthur A.
, p. 2175 - 2179 (2007/10/03)
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