117830-18-9

Basic information

• Product Name: 3-Pyridinecarboxylicacid,5-chloro-,hydrazide(9CI)
• Synonyms: 3-Pyridinecarboxylicacid,5-chloro-,hydrazide(9CI);5-chloronicotinohydrazide
• CAS NO: 117830-18-9
• Molecular Formula: C₆H₆ClN₃O
• Molecular Weight: 171.58
• Product Categories: HYDRAZINE
• Mol File: 117830-18-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.404±0.06 g/cm3(Predicted)
• PKA: 10?+-.0.10(Predicted)
• CAS DataBase Reference: 3-Pyridinecarboxylicacid,5-chloro-,hydrazide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylicacid,5-chloro-,hydrazide(9CI)(117830-18-9)
• EPA Substance Registry System: 3-Pyridinecarboxylicacid,5-chloro-,hydrazide(9CI)(117830-18-9)

Safety Data

• Hazardous Substances Data: 117830-18-9(Hazardous Substances Data)

Upstream product

• 20825-98-3 5-chloro-nicotinic acid ethyl ester 
• 22620-27-5 5-chloronicotinic acid 
• 51269-81-9 methyl 5-chloropyridine-3-carboxylate 

Downstream Products

• 118420-18-1 C₁₃H₁₂ClN₃O₃S 
• 113118-82-4 3-chloro-5-pyridinecarboxaldehyde 
• 118420-36-3 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(5-chloro-pyridin-3-yl)-acrylamide 
• 1423715-17-6 (E)-5-chloro-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)nicotinohydrazide 

Relevant articles and documents

[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES

The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Pyrido[4,3- e ][1,2,4]triazolo[4,3- a ]pyrazines as selective, brain penetrant phosphodiesterase 2 (PDE2) inhibitors

A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the phenyl ring pending from the triazole. The SAR and protein flexibility were explored with free energy perturbation calculations. Rat pharmacokinetic data and in vivo receptor occupancy data are given for two representative compounds 6 and 12.

SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS

In one aspect, the invention relates to substituted (E)-N'-(1- phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods fo