117836-15-4Relevant articles and documents
Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones
Sleebs, Brad E.,Nguyen, Nghi H.,Hughes, Andrew B.
, p. 6275 - 6284 (2013/07/27)
The 4-substituted-1,3-oxazinan-6-one scaffold is a versatile synthon enabling access to a diverse array of β-amino acid derivatives. In this study, the synthetic utility of the 1,3-oxazinan-6-one is expanded to include the diastereoselective synthesis of
Design and synthesis of cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents
Bavetsias, Vassilios,Marriott, Jonathan H.,Melin, Camille,Kimbell, Rosemary,Matusiak, Zbigniew S.,Boyle, F. Thomas,Jackman, Ann L.
, p. 1910 - 1926 (2007/10/03)
Following the development of raltitrexed, the synthesis of nonpolyglutamatable inhibitors of TS that do not use the reduced folate carrier (RFC) for cellular entry should provide compounds which overcome mechanisms of resistance to folate-based inhibitors
Synthesis of [6-13C]-L-lysine
Sutherland,Willis
, p. 95 - 102 (2007/10/03)
A short and efficient enantioselective synthesis of [6-13C]-L-lysine from commercially available N-benzyloxycarbonyl-L-glutamic acid α-methyl ester is described using [13C]-sodium syanide as the source of isotopic label.