1186412-30-5Relevant articles and documents
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)
McGuigan, Christopher,Kelleher, Mary Rose,Perrone, Plinio,Mulready, Sinead,Luoni, Giovanna,Daverio, Felice,Rajyaguru, Sonal,Pogam, Sophie Le,Najera, Isabel,Martin, Joseph A.,Klumpp, Klaus,Smith, David B.
experimental part, p. 4250 - 4254 (2010/04/02)
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4′-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-μM inhibitors of HCV emerge.