478182-28-4

Basic information

• Product Name: 4'-Azidocytidine
• Synonyms: 4'-Azidocytidine;R-1479;4'-alpha-Azido-cytidine;Cytidine, 4'-C-azido-;4'-C-azidocytidine
• CAS NO: 478182-28-4
• Molecular Formula: C₉H₁₂N₆O₅
• Molecular Weight: 284.22878
• Mol File: 478182-28-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-Azidocytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Azidocytidine(478182-28-4)
• EPA Substance Registry System: 4'-Azidocytidine(478182-28-4)

Safety Data

• Hazardous Substances Data: 478182-28-4(Hazardous Substances Data)

Usage

General Description

4'-Azidocytidine, also known as 4'-N3-Cytidine or Rovidecine, is a chemical compound with potential antiviral and anti-cancer properties. It's a potent viral polymerase inhibitor, which means it can interfere with the replication process of various viruses, including the SARS-CoV-2 virus, which causes COVID-19. Its mechanism involves integrating into the virus's RNA and causing premature termination during replication. Studies are being conducted to explore its full therapeutic potential and side effects, but initial results indicate its potential in antiviral drug development.

Upstream product

• 690270-27-0 acetic acid (2R,2S,4R,5R)-4-acetoxy-2-acetoxymethyl-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azidotetrahydrofuran-3-yl ester 
• 690271-25-1 (2R,3R,4S,5R)-4-acetoxy-5-acetoxymethyl-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-3-yl acetate 
• 478182-26-2 C₂₃H₁₉N₅O₈ 
• 139442-01-6 1-(4'-azido-β-D-ribofuranosyl)uracil 
• 139419-04-8 4'-azido-5'-deoxy-5'-iodouridine 
• 139419-02-6 4'-azido-2',3'-di-O-benzoyl-5'-deoxy-5'-iodouridine 
• 14365-63-0 5'-deoxyuridin-4'-ene 
• 690270-09-8 benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester 
• 58-96-8 uridine 

Downstream Products

• 690270-29-2 balapiravir 
• 1186412-30-5 C₂₅H₂₇ClN₇O₉P 
• 1186412-24-7 C₂₂H₃₀N₇O₉P 
• 1186412-08-7 C₂₉H₃₄N₇O₉P 

Relevant articles and documents

4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION

The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.

AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS

Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of amelioratin

PROCESS FOR PREPARATION OF 4'-AZIDO CYTIDINE DERIVATIVES

The invention relates to a novel process for the preparation of a 4'-azido cytidine of the formula (I) of a hydrate or of a pharmaceutically accepted salt thereof. The 4'-azido cytidine of formula (I) is useful for treating virus mediated diseases, particularly for treating HCV mediated diseases.