478182-26-2Relevant articles and documents
Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479
Smith, David B.,Martin, Joseph A.,Klumpp, Klaus,Baker, Stewart J.,Blomgren, Peter A.,Devos, Rene,Granycome, Caroline,Hang, Julie,Hobbs, Christopher J.,Jiang, Wen-Rong,Laxton, Carl,Pogam, Sophie Le,Leveque, Vincent,Ma, Han,Maile, Graham,Merrett, John H.,Pichota, Arkadius,Sarma, Keshab,Smith, Mark,Swallow, Steven,Symons, Julian,Vesey, David,Najera, Isabel,Cammack, Nick
, p. 2570 - 2576 (2007)
A series of 4′-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4′-azidocytidine, R1479) with an
