139419-02-6

Basic information

• Product Name: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate
• Synonyms: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate;(2S,3S,4R,5R)-2-azido-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(iodomethyl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS NO: 139419-02-6
• Molecular Formula: C₂₃H₁₈IN₅O₇
• Molecular Weight: 603.32279
• Mol File: 139419-02-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(139419-02-6)
• EPA Substance Registry System: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(139419-02-6)

Safety Data

• Hazardous Substances Data: 139419-02-6(Hazardous Substances Data)

Usage

General Description

Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate is a chemical compound that contains uridine, a nucleoside found in RNA, with azido and iodo substituents at the 4' and 5' positions of the sugar moiety, and dibenzoate groups at the 2' and 3' positions. Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate is commonly used in chemical and biological research to study nucleic acid structure and function. In particular, its modified structure allows researchers to investigate nucleic acid-protein interactions and develop new tools and technologies for biotechnology and medical applications. Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate can also serve as a valuable building block for the synthesis of other nucleoside analogs and derivatives with potential pharmaceutical or diagnostic uses.

Upstream product

• 98-88-4 benzoyl chloride 
• 139419-04-8 4'-azido-5'-deoxy-5'-iodouridine 
• 14365-63-0 5'-deoxyuridin-4'-ene 
• 14259-58-6 1-((2R,3R,4S,5S)-3,4-dihydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 

Downstream Products

• 139442-01-6 1-(4'-azido-β-D-ribofuranosyl)uracil 
• 478182-26-2 C₂₃H₁₉N₅O₈ 
• 478182-28-4 4'-azidocytidine 
• 812647-80-6 1-(4’-azido-5‘-O-(3-chloro)benzoyl-2’,3‘-O-dibenzoyl-β-D-ribofuranosyl)uracil 
• 1365255-42-0 C₃₀H₂₃N₅O₉ 
• 690270-09-8 benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester 

Relevant articles and documents

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

Anti-viral nucleosides

4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are comp

4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication

The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically a