1194488-55-5Relevant articles and documents
Convergent kilo-scale synthesis of a potent renin inhibitor for the treatment of hypertension
Campeau, Louis-Charles,Dolman, Sarah J.,Gauvreau, Danny,Ouellet, Stephane G.,O'Shea, Paul D.,Corley, Ed,Liu, Jinchu,Guidry, Erin N.,Steinhuebel, Dietrich,Weisel, Mark
, p. 1138 - 1148 (2012/01/05)
Process research and development of a synthetic route towards a novel renin inhibitor (1) is described. The highly convergent synthetic route provided 1 in 15% yield on multikilogram scale with a longest linear sequence of 11 steps. The use of catalytic h
3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS
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, (2010/01/29)
The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.