1229245-21-9Relevant articles and documents
Convergent kilo-scale synthesis of a potent renin inhibitor for the treatment of hypertension
Campeau, Louis-Charles,Dolman, Sarah J.,Gauvreau, Danny,Ouellet, Stephane G.,O'Shea, Paul D.,Corley, Ed,Liu, Jinchu,Guidry, Erin N.,Steinhuebel, Dietrich,Weisel, Mark
experimental part, p. 1138 - 1148 (2012/01/05)
Process research and development of a synthetic route towards a novel renin inhibitor (1) is described. The highly convergent synthetic route provided 1 in 15% yield on multikilogram scale with a longest linear sequence of 11 steps. The use of catalytic h
3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS
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Page/Page column 67-68, (2009/12/27)
The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well a