119549-47-2Relevant articles and documents
Potent dipeptide inhibitors of the pp60(c-src) SH2 domain
Pacofsky, Gregory J.,Lackey, Karen,Alligood, Krystal J.,Berman, Judd,Charifson, Paul S.,Crosby, Renae M.,Dorsey Jr., George F.,Feldman, Paul L.,Gilmer, Tona M.,Hummel, Conrad W.,Jordan, Steven R.,Mohr, Christopher,Shewchuk, Lisa M.,Sternbach, Daniel D.,Rodriguez, Marc
, p. 1894 - 1908 (1998)
The design, synthesis, and evaluation of dipeptide analogues as ligands for the pp60(c-src) SH2 domain are described. The critical binding interactions between Ac-Tyr-Glu-N(n-C5H11)2 (2) and the protein are established and
Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors
Puig De La Bellacasa, Raimon,Gibert, Albert,Planesas, Jesús M.,Ros-Blanco, Laia,Batllori, Xavier,Badía, Roger,Clotet, Bonaventura,Esté, José,Teixidó, Jordi,Borrell, José I.
, p. 1455 - 1472 (2016/02/03)
The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined for the more flexible and less bulky structures 4, p
Small peptides containing phosphotyrosine and adjacent αMe- phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain
Liu, Wang-Qing,Vidal, Michel,Gresh, Nohad,Roques, Bernard P.,Garbay, Christiane
, p. 3737 - 3741 (2007/10/03)
A series of small peptides with the sequence mAZ-pTyr-Xaa-Asn-NH2, where Xaa denotes α-methylphosphotyrosine or its carboxylic mimetics, were synthesized as inhibitors of the Grb2 SH2 domain. Peptide 3 with (α-Me)pTyr as Xaa has the highest aff
