121-87-9Relevant articles and documents
Kinetic study and mechanism of Niclosamide degradation
Zaazaa, Hala E.,Abdelrahman, Maha M.,Ali, Nouruddin W.,Magdy, Maimana A.,Abdelkawy
, p. 655 - 662 (2014)
A spectrophotometric kinetic study of Niclosamide alkaline degradation as a function of drug concentration, alkaline concentration and temperature has been established utilizing double divisor-ratio spectra spectrophotometric method. The developed method allowed determination of Niclosamide in presence of its alkaline degradation products; namely; 2-chloro-4-nitro aniline (DEG I) and 5-chloro salicylic acid (DEG II) with characterization of its degradation mechanism. It was found that degradation kinetic of Niclosamide followed pseudo-first order under the established experimental conditions with a degradation rate constant (k) of 0.0829 mol/h and half life (t1/2) of 8.35 h. The overall degradation rate constant as a function of the temperature under the given conditions obeyed Arrhenius equation where the activation energy was calculated to be 3.41 kcal/mol.
Sodium lauryl sulfate-catalyzed oxidative chlorination of aromatic compounds
Mahajan, Tanu,Kumar, Lalit,Dwivedi, K.,Agarwal, D. D.
, p. 3655 - 3663,9 (2012)
Chlorination of commercially important aromatic compounds using sodium chloride as chlorine source and sodium periodate as oxidant in acidic medium catalyzed by sodium lauryl sulfate (SLS) led to the chloro-substituted aromatics in good yields and purity. Addition of sodium lauryl sulfate led to increased chlorination rate, better yield, excellent purity, and better quality of end product. The advantages of the present method are greater yield, excellent purity, and shorter reaction time at room temperature. Also dichlorinated product can be obtained by increasing the amount of sodium chloride and sodium periodate at slightly higher temperature (40C).
Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups
Govindan, Karthick,Chen, Nian-Qi,Chuang, Yu-Wei,Lin, Wei-Yu
supporting information, p. 9419 - 9424 (2021/11/30)
We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.
Environment-friendly preparation method of 2-chloro-4-nitro-6-bromoaniline
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Paragraph 0040; 0043; 0046; 0049; 0051; 0054; 0056; 0059, (2020/05/02)
A preparation method of 2-chloro-4-nitro-6-bromoaniline comprises the following steps: (a) carrying out mixed acid nitration on o-dichlorobenzene, and continuing to apply the generated waste acid to anext nitration reaction; (b) purifying the obtained nitration product in an alcohol solvent to obtain 3,4-dichloronitrobenzene, and continuously applying the recovered alcohol solvent to a next purification process; (c) carrying out ammonolysis on the 3,4-dichloronitrobenzene in a water phase by adopting a specific catalyst to prepare o-chloro-p-nitroaniline, and continuously applying the recycled liquid ammonia to a next ammonolysis reaction; and (d) brominating o-chloro-p-nitroaniline in a hydrogen bromide and oxidant system, and recycling brominated waste acid liquid and bromine for a nextbromination reaction. The product obtained by the method is good in yield, high in purity and high in quality; and two waste acids and bromine in the product are recycled, so that the amount of wastewater is reduced. Compared with traditional processes, the method has obvious quality and environmental protection advantages, and has high production safety.