881-87-8

Basic information

• Product Name: N-(2-chloro-4-nitrophenyl)acetamide
• Synonyms: N1-(2-chloro-4-nitrophenyl)acetamide
• CAS NO: 881-87-8
• Molecular Formula: C₈H₇ClN₂O₃
• Molecular Weight: 214.6058
• Mol File: 881-87-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 408.4°C at 760 mmHg
• Flash Point: 200.8°C
• Density: 1.466g/cm³
• Vapor Pressure: 7.04E-07mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: N-(2-chloro-4-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-4-nitrophenyl)acetamide(881-87-8)
• EPA Substance Registry System: N-(2-chloro-4-nitrophenyl)acetamide(881-87-8)

Safety Data

• Hazardous Substances Data: 881-87-8(Hazardous Substances Data)

Usage

General Description

N-(2-chloro-4-nitrophenyl)acetamide is a chemical compound with the molecular formula C8H7ClN2O3. It is a yellow crystalline solid with a slight odor, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. N-(2-chloro-4-nitrophenyl)acetamide is known for its antibacterial and antifungal properties, making it a valuable component in the development of medical and agricultural products. N-(2-chloro-4-nitrophenyl)acetamide is also used in research and laboratory settings as a reagent in organic synthesis. However, it is important to handle this compound with caution as it may be hazardous if not properly handled and stored.

Upstream product

• 533-17-5 N-(2-chlorophenyl)acetamide 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 79272-04-1 N-chloro-p-nitroacetanilide 
• 108-24-7 acetic anhydride 
• 121-87-9 2-Chloro-4-nitroaniline 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 2754-27-0 trimethylsilyl acetate 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 99-54-7 3,4-dichloronitrobenzene 
• 95-51-2 o-chloroaniline 

Downstream Products

• 121-87-9 2-Chloro-4-nitroaniline 
• 57556-49-7 N-(4-Amino-2-chloro-phenyl)-acetamide 
• 87223-53-8 C₁₃H₁₅ClN₄O₅ 
• 20201-04-1 1,2-bis(2-chloro-4-nitrophenyl)disulfane 
• 408350-99-2 2-chloro-4-nitro-phenyl thiocyanate 
• 1432135-75-5 N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4.3-b]pyridin-3-yl]amino}phenyl)acetamide 
• 1432112-24-7 2-chloro-N⁴-[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]benzene-1,4-diamine 
• 1432112-27-0 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione 
• 1432112-28-1 2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide 

Relevant articles and documents

Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)

N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) has been explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and commercially available N-chloro reagents to reveal the reactivity on a theoretical viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-butyl hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent.

Variable noninnocence of substituted azobis(phenylcyanamido)diruthenium complexes

The synthetic chemistry of substituted 4,4′-azobis(phenylcyanamide) ligands was investigated, and the complexes [{Ru(tpy)(bpy)}2( μ-L)][PF6]2, where L = 2,2′:5,5′-tetramethyl-4,4′-azobis(phenylcyanamido) (Me4adpc2-), 2,2′-dimethyl-4,4′-azobis(phenylcyanamido) (Me2adpc2-), unsubstituted (adpc2-), 3,3′-dichloro-4,4′-azobis(phenylcyanamido) (Cl2adpc2-), and 2,2′:5,5′-tetrachloro-4,4′-azobis(phenylcyanamido) (Cl4adpc2-), were prepared and characterized by cyclic voltammetry and vis-near-IR (NIR) and IR spectroelectrochemistry. The room temperature electron paramagnetic resonance spectrum of [{Ru(tpy)(bpy)}2( μ-Me4adpc)]3+ showed an organic radical signal and is consistent with an oxidation-state description [RuII, Me4adpc?-, RuII]3+, while that of [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ at 10 K showed a low-symmetry RuIII signal, which is consistent with the description [RuIII, Cl2adpc2-, RuII]3+. IR spectroelectrochemistry data suggest that [{Ru(tpy)(bpy)}2( μ-adpc)]3+ is delocalized and [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ and [{Ru(tpy)(bpy)}2( μ-Cl4adpc)]3+ are valence-trapped mixed-valence systems. A NIR absorption band that is unique to all [{Ru(tpy)(bpy)}2( μ-L)]3+ complexes is observed; however, its energy and intensity vary depending on the nature of the bridging ligand and, hence, the complexes oxidation-state description.

ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

Disclosed are compounds of Formula (I), and salts thereof, wherein R1, RA2, RA3 and RA4, are defined herein, which have properties for positive allosteric modulation of mGluR-4 receptor sites. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating Parkinson's disease and related disorders using the same.