121041-28-9

Basic information

• Product Name: 3-methoxy-6-(3'-methoxybenzylthio)-2-(pyridin-4''-yl)imidazo<1,2-b>pyridazine
• CAS NO: 121041-28-9
• Molecular Weight: 378.455
• Mol File: 121041-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methoxy-6-(3'-methoxybenzylthio)-2-(pyridin-4''-yl)imidazo<1,2-b>pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-6-(3'-methoxybenzylthio)-2-(pyridin-4''-yl)imidazo<1,2-b>pyridazine(121041-28-9)
• EPA Substance Registry System: 3-methoxy-6-(3'-methoxybenzylthio)-2-(pyridin-4''-yl)imidazo<1,2-b>pyridazine(121041-28-9)

Safety Data

• Hazardous Substances Data: 121041-28-9(Hazardous Substances Data)

Upstream product

• 824-98-6 m-methoxybenzyl chloride 
• 121041-65-4 6-(3'-methoxybenzylthio)pyridazin-3-amine 2-oxide 
• 5349-17-7 4-bromoacetylpyridine hydrobromide 
• 7166-64-5 m-methoxytoluene-α-thiol 
• 1122-54-9 methyl (4-pyridyl) ketone 

Relevant articles and documents

Imidazopyridazines. VI. Syntheses and Central Nervous System Activities of Some 6-(Alkoxy- and methylthio-phenoxy and methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines

Series of 6-(alkoxy- and methylthio-phenoxy)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines and 3-methoxy-6-(methoxybenzylthio)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines have been prepared and subsesquently tested for their ability to inhibit GABA-stimulated 3H-diazepam binding to rat brain plasma membranes.The 6-(alkoxy- and methylthio-phenoxy) and 6-(methoxybenzylthio) compounds were much more effective in the displacement studies than the parent 6-phenoxy or 6-benzylthio compounds respectively.3-Methoxy-6-(2'-methoxyphenoxy)-2-phenylimidazopyridazine (GBLD-167, IC50 70 nM) was 16 times more effective than its 3-methoxy-6-phenoxy analogue (GBLD-214, IC50 1120 nM) and the 3-methoxy-6-(2'-methoxybenzylthio)-2-phenyl compound (GBLD-163, IC50 9 nM) was two and a half times more active than its 6-benzylthio-3-methoxy analogue (GBLD-137, IC50 22nM).The most active member of the 6-phenoxy series was the 2-(4'-fluorophenyl)-3-methoxy-6-(2''-methoxyphenoxy) compound (GBLD-255, IC50 30nM) and, within the 6-benzylthio series, the 2-(4'-fluorophenyl, 3'-aminophenyl, and pyridin-3'-yl)-3-methoxy-6-(3''-methoxybenzylthio) compounds (GBLD-233, 301 and 296) all gave IC50 5nM.A Hansch-type analysis of the results for these two closely related series of compounds indicates that electron-donating substituents in 2-(para substituted phenyl) derivatives favour binding, but bulky substituents hinder this effect.