1222858-35-6

Basic information

• Product Name: C₂₂H₁₈O₃S
• Synonyms: C₂₂H₁₈O₃S
• CAS NO: 1222858-35-6
• Molecular Weight: 362.449
• Mol File: 1222858-35-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈O₃S(1222858-35-6)
• EPA Substance Registry System: C₂₂H₁₈O₃S(1222858-35-6)

Safety Data

• Hazardous Substances Data: 1222858-35-6(Hazardous Substances Data)

Upstream product

• 4897-68-1 2-iodo-4-methoxybromobenzene 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 1163700-88-6 C₁₆H₁₃BrO₂ 
• 1163701-07-2 C₁₇H₁₆O₂S 
• 1163701-26-5 C₁₆H₁₃IO₂S 
• 182281-01-2 4-(tetrahydro-2H-pyran-2-yloxy)phenylboronic acid 

Downstream Products

• 1261352-34-4 C₂₉H₃₁NO₃S 
• 1314775-05-7 C₂₈H₂₉NO₄S 

Relevant articles and documents

Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling

For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr3.