1225-03-2 Usage
Description
(9β)-3-Hydroxyestra-1,3,5(10)-trien-17-one, also known as 9β-estrone, is a naturally occurring steroid hormone and a derivative of estrogen. It is an essential hormone in the human body, playing a crucial role in the regulation of the menstrual cycle, fertility, and the development of secondary sexual characteristics in females. Additionally, it contributes to the maintenance of bone density and the regulation of cholesterol levels.
Uses
Used in Hormone Regulation:
9β-estrone is used as a hormone regulator for [application reason] in the human body. It is involved in the regulation of the menstrual cycle, fertility, and the development of secondary sexual characteristics in females.
Used in Bone Health:
9β-estrone is used as a bone health promoter for maintaining bone density, which is essential for preventing osteoporosis and other bone-related conditions.
Used in Cholesterol Regulation:
9β-estrone is used as a cholesterol regulator for managing cholesterol levels in the body, which can help prevent cardiovascular diseases.
Used in Hormone Replacement Therapy:
9β-estrone is used as a hormone replacement agent for treating conditions related to hormonal imbalances, such as menopause or other hormone-related disorders.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 9β-estrone is used as an active pharmaceutical ingredient for the development of drugs targeting hormone-related conditions and disorders.
Used in Research and Development:
9β-estrone is used as a research compound for studying the effects of estrogen on various physiological processes and for developing new therapies for hormone-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1225-03-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1225-03:
(6*1)+(5*2)+(4*2)+(3*5)+(2*0)+(1*3)=42
42 % 10 = 2
So 1225-03-2 is a valid CAS Registry Number.
1225-03-2Relevant articles and documents
Structure-activity relationships of 9β-estrogens
Gabbard,Segaloff
, p. 555 - 563 (1983)
The 9β isomers of estradiol-17β, estradiol-17α, estrone and 17-ethinylestradiol-17β were synthesized and compared with their 9α-counterparts in the rat uterine cytosol estrogen receptor, uterotropic, and gonadotropin release inhibition assays. Except for 17-ethinyl-9β-estradiol-17β which was as active as its 9α isomer in the uterotropic assay, none of the 9β estrogens exhibited any biological activity which was equal to or greater than their 9α counterparts. For examples, 9β-estradiol-17β was 1/10 as active as estradiol-17β, and 9β-estrone was 1/4 as active as estrone in the uterotropic assay.
Solvent- and Wavelength-Dependent Photolysis of Estrone
Adriano, Natalie,Ahearn, Ceilidh,Black, Cory,Cracchiolo, Michael,Ghere, Daniel,Hare, Patrick M.,Nu?ez, Alexandra,Olivan, Lars,Patel, Raj,Saner, Stephanie,Smith, Krista R.,Watkins, Barbie
, (2021/11/08)
The direct photolysis of estrone in solvents ranging from water to cyclohexane is reported. The photodegradation is dominated by lumiestrone, an epimer of estrone resulting from the inversion of the methyl group at carbon 13, regardless of solvent and pho
Pd-catalyzed Suzuki–Miyaura couplings and evaluation of 13α-estrone derivatives as potential anticancer agents
Ali, Hazhmat,Horváth, Gergely,Jójárt, Rebeka,Kele, Zoltán,Mernyák, Erzsébet,Zupkó, István
, (2020/10/02)
13α-Estrones are of great value owing to their potent multiple bioactivity, including anticancer activity. 3-OH or 3-OBn derivatives of 2- or 4-[(subst.) phenyl]-13α-estrone as potential antiproliferative agents have been synthesized via facile, microwave
