53-63-4

Basic information

• Product Name: 17-desoxyestradiol
• Synonyms: ESTRA-1,3,5(10)-TRIEN-3-OL;17-Deoxyestradiol;17-Deoxyestrone;17-Deoxyoestrone
• CAS NO: 53-63-4
• Molecular Formula: C₁₈H₂₄O
• Molecular Weight: 256.38256
• Mol File: 53-63-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 135.5-137 °C
• Boiling Point: 399.8°Cat760mmHg
• Flash Point: 188.8°C
• Appearance: /
• Density: 1.087g/cm³
• Vapor Pressure: 5.76E-07mmHg at 25°C
• Refractive Index: 1.575
• PKA: 10.30±0.40(Predicted)
• CAS DataBase Reference: 17-desoxyestradiol(CAS DataBase Reference)
• NIST Chemistry Reference: 17-desoxyestradiol(53-63-4)
• EPA Substance Registry System: 17-desoxyestradiol(53-63-4)

Safety Data

• Hazardous Substances Data: 53-63-4(Hazardous Substances Data)

Usage

Description

17-desoxyestradiol is a 3-hydroxy steroid that is formed through the deoxygenation at position 17 of estradiol or estrone. It is a naturally occurring compound with significant biological activity and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
17-desoxyestradiol is used as a pharmaceutical agent for its hormonal activity. It can be utilized in the development of drugs targeting hormonal imbalances and related conditions due to its structural similarity to estradiol and estrone.
Used in Research Applications:
In the field of research, 17-desoxyestradiol serves as an important tool for studying the mechanisms of steroid hormone action and their effects on various physiological processes. It aids scientists in understanding the role of hormones in health and disease.
Used in Hormone Replacement Therapy:
17-desoxyestradiol can be employed as a component in hormone replacement therapies, particularly for conditions that involve a deficiency or imbalance of sex hormones. Its ability to mimic the effects of estradiol and estrone makes it a potential candidate for such treatments.
Used in Cosmetic Industry:
Due to its hormonal properties, 17-desoxyestradiol may also find applications in the cosmetic industry for anti-aging and skin care products. It could potentially be used to develop formulations that promote skin health and address aging-related concerns.

InChI:InChI=1/C18H24O/c1-18-9-2-3-17(18)16-6-4-12-11-13(19)5-7-14(12)15(16)8-10-18/h5,7,11,15-17,19H,2-4,6,8-10H2,1H3/t15-,16-,17+,18+/m1/s1

Upstream product

• 53-16-7 Estrone 
• 141-52-6 sodium ethanolate 
• 75-77-4 chloro-trimethyl-silane 
• 14550-57-3 3-methoxy-1,3,5(10)-estratriene 
• 71-36-3 butan-1-ol 
• 7628-02-6 17β-hydrazoestra-1,3,5(10)-trien-3-ol 
• 50394-95-1 3-hydroxyestra-1,3,5⁽¹⁰⁾-trienyl toluene-p-sulfonate 
• 4954-14-7 (8R,9S,13S,14S,17S)-3,17-dimethoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene 
• 53-16-7 rac-3-hydroxy-8α,9β-estra-1,3,5(10)-trien-17-one 

Downstream Products

• 111200-38-5 5ξ,10ξ-estranol-(3ξ) 
• 14550-57-3 3-methoxy-1,3,5(10)-estratriene 
• 29755-24-6 3-(trimethylsiloxy)estra-1,3,5(10)-triene 
• 6561-98-4 10-Acetoxy-Δ^1,4-oestradienon-(3) (Oestra-p-chinolacetat) 
• 6561-96-2 2',4'-Dinitro-benzol-(1'-azo-3)-Δ^1,3,5(10)-oestratrien 
• 536739-81-8 ((8S,9S,13S,14S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-acetic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester 
• 134223-97-5 pyridinium 3-methoxyestra-1,3,5(10)-trien-6α-yl sulfate 
• 5506-56-9 2-Hydroxy-3-<4-nitro-2-benzoyl-phenoxy>-oestratrien-<1,3,5(10)> 
• 4999-72-8 2-Methoxy-3-<4-nitro-2-benzoyl-phenoxy>-oestratrien-<1,3,5(10)> 
• 1417896-42-4 C₂₆H₃₂O₂ 
• 1417896-43-5 C₂₈H₃₀F₆O₂ 
• 1417896-44-6 C₂₇H₃₄O₃ 
• 1417896-45-7 C₂₉H₃₈O₅ 
• 1417896-32-2 C₂₄H₂₈O 

Relevant articles and documents

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Nickel-Catalyzed Intramolecular Decarbonylative Coupling of Aryl Selenol Esters

This report describes a method for Ni-catalyzed intramolecular decarbonylative coupling, which enables the conversion of areneselenol esters to diaryl selenides. The inexpensive and readily available catalyst can be employed under mild reaction conditions for the construction of structurally diverse diaryl selenides, including heterocyclic and natural product derivatives. (Figure presented.).

Selectivity and Mechanism of Iridium-Catalyzed Cyclohexyl Methyl Ether Cleavage

Cationic bis(phosphine)iridium complexes are found to catalyze the cleavage of cyclohexyl methyl ethers by triethylsilane. Selectivity for C-O cleavage is determined by the relative rates of SN2 demethylation versus SN1 demethoxylation, with the axial or equatorial disposition of the silyloxonium ion intermediate acting as an important contributing factor. Modulation of the electron-donor power of the supporting phosphine ligands enables a switch in selectivity from demethylation of equatorial methyl ethers to 2° demethoxylation. Applications of these accessible catalysts to the selective demethoxylation of the 3α-methoxy group of cholic acid derivatives is demonstrated, including a switch in observed selectivity controlled by 7α-substitution. The resting state of the catalyst has been characterized for two phosphine derivatives, demonstrating that the observed switch in C-O cleavage selectivity likely results from electronic factors rather than from a major perturbation of the catalyst structure.

Reducing dehalogenating method of organic halogenated compound

The invention discloses a reducing dehalogenating method of an organic halogenated compound. The reducing dehalogenating method comprises: mixing an organic halogenated compound R-X, a non-noble metalpromoter, a sulfide and an alkali, and carrying out a reducing dehalogenating reaction to obtain a reducing product R-H, wherein R is at least one selected from alkyl and aryl, and X is at least oneselected from iodine, bromine and chlorine. According to the present invention, the types and the ratio (especially the specific type of the promoter) of various raw materials used in the reducing dehalogenating reaction, the corresponding reaction conditions and the like are researched and improved, such that the problems of use of highly-toxic or expensive reagent, poor tolerance of the group, narrow application range of the substrate and the like in the prior art can be effectively solved.