123168-30-9

Basic information

• Product Name: 5-Deoxy-L-ribose phenylhydrazone
• Synonyms: 5-Deoxy-L-ribose phenylhydrazone
• CAS NO: 123168-30-9
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.25634
• Mol File: 123168-30-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 474.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 12.56±0.20(Predicted)
• CAS DataBase Reference: 5-Deoxy-L-ribose phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Deoxy-L-ribose phenylhydrazone(123168-30-9)
• EPA Substance Registry System: 5-Deoxy-L-ribose phenylhydrazone(123168-30-9)

Safety Data

• Hazardous Substances Data: 123168-30-9(Hazardous Substances Data)

Usage

Description

5-Deoxy-L-ribose phenylhydrazone is an organic compound that serves as an intermediate in the synthesis of various biologically active molecules. It is characterized by its ability to form phenylhydrazone derivatives, which are useful in the chemical analysis and synthesis of different compounds.

Uses

Used in Pharmaceutical Industry:
5-Deoxy-L-ribose phenylhydrazone is used as an intermediate for the synthesis of L-Primapterin (P733000), which belongs to the 7-Substituted pterins. This new class of mammalian pteridines has been identified in patients with hyperphenylalaninemia, a metabolic disorder characterized by elevated levels of phenylalanine in the blood. The compound plays a crucial role in the development of potential therapeutic agents for the treatment of this condition.
Additionally, 5-Deoxy-L-ribose phenylhydrazone can be used as a building block for the synthesis of other biologically active molecules, contributing to the advancement of pharmaceutical research and drug development. Its versatility in forming phenylhydrazone derivatives makes it a valuable compound in the synthesis of various organic compounds with potential applications in the pharmaceutical industry.

Upstream product

• 13039-56-0 5-deoxy-L-arabinose 
• 100-63-0 phenylhydrazine 
• 93978-94-0 5-deoxy-L-ribose 
• 38279-72-0 2,3-cyclohexylidene-5-deoxy-L-ribose 
• 4159-66-4 (R)-1-((4R,5S)-5-((S)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol 

Downstream Products

• 22150-76-1 biopterin 
• 81827-31-8 2-N-acetyl-1',2'-di-O-acetyl-L-erythro-biopterin 
• 94591-24-9 Biolumazin 
• 94591-29-4 2-N-Benzoyl-1',2'-di-O-benzoylbiopterin 
• 94591-31-8 2-N-Benzoyl-1',2'-di-O-benzoyl-4-thiobiopterin 
• 62933-57-7 1',2'-O-diacetyl-L-biopterin 
• 22150-76-1 L-erythro biopterin 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF SAPROPTERIN DIHYDROCHLORIDE AND ITS KEY INTERMEDIATE, L-BIOPTERIN

The present invention relates to a novel process for the preparation of Sapropterin dihydrochloride of formula (1) and its key intermediate L-erythro-biopterin of formula (2). The present process is a simple and economically viable process for commercial production of Sapropterin dihydrochloride of formula (1) and its key intermediate L-biopterin of formula (2).

Pteridines, LXXV. - Synthesis and Properties of Biopterin and Biopterin Analogs

The synthesis of biopterin (6), its 2-N,N-dimethyl- (8) and 4-thioxo derivative (19) as well as biolumazine (7) is described.The side chain of biopterin can be modified by reaction of α-acetoxy-isobutyryl chloride to yield 6-(L-threo-2-acetoxy-1-chloropropyl)pterin (10), which can be used as a starting material for further derivatisations. 2,1',2'-Triacylbiopterins (14, 16) possess a hydrolytically labile N-acyl group.The newly synthesized compounds were characterized by pK-determinations, UV, and NMR spectra.