93978-94-0Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF SAPROPTERIN DIHYDROCHLORIDE AND ITS KEY INTERMEDIATE, L-BIOPTERIN
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Page/Page column 10; 15; 22, (2016/12/22)
The present invention relates to a novel process for the preparation of Sapropterin dihydrochloride of formula (1) and its key intermediate L-erythro-biopterin of formula (2). The present process is a simple and economically viable process for commercial production of Sapropterin dihydrochloride of formula (1) and its key intermediate L-biopterin of formula (2).
Highly α-selective hydrolysis of α,β-epoxyalcohols using tetrabutylammonium fluoride
Mukerjee, Purba,Abid, Mohammed,Schroeder, Frank C.
supporting information; experimental part, p. 3986 - 3989 (2010/11/04)
We report a simple method for the highly regio- and stereoselective hydrolysis of α,β-epoxyalcohols. Treatment of enantiopure epoxyalcohols derived from Sharpless epoxidation with TBAF/H2O resulted in exclusive ring opening at the normally disfavored α-position, providing access to arabino- or lyxo-configured triols with full preservation of stereochemical purity. The method was applied in syntheses of 5-deoxy-l-arabinose (26) and a family of bicyclic acetals based on the insect pheromone hydroxybrevicomin (4).
Total synthesis of L-biopterin from L-tartaric acid via 5-deoxy-L-arabinose
Fernandez, Anne-Marie,Duhamel, Lucette
, p. 8698 - 8700 (2007/10/03)
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