1233955-69-5

Basic information

• Product Name: tert-butyl 4-[(methylcarbamoyl)amino]piperidine-1-carboxylate
• CAS NO: 1233955-69-5
• Molecular Weight: 257.333
• Mol File: 1233955-69-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-[(methylcarbamoyl)amino]piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-[(methylcarbamoyl)amino]piperidine-1-carboxylate(1233955-69-5)
• EPA Substance Registry System: tert-butyl 4-[(methylcarbamoyl)amino]piperidine-1-carboxylate(1233955-69-5)

Safety Data

• Hazardous Substances Data: 1233955-69-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 6452-47-7 methylcarbamoyl chloride 
• 74-89-5 methylamine 
• 670253-16-4 4-[(phenoxycarbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester 
• 180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 90633-18-4 4-bromo-1H-piperidine 
• 624-83-9 methyl isocyanate 

Relevant articles and documents

Discovery of SHR0687, a Highly Potent and Peripheral Nervous System-Restricted KOR Agonist

Analgesics with no abuse liability are highly demanded in the market. KOR agonists have been proved to be strong analgesics without MOR agonist-related side effects, such as respiratory depression, tolerance, and dependence liability; however, activation

Synthesis method of 1-methyl-3-(piperidine-4-yl) urea hydrochloride

The invention relates to a synthesis method of 1-methyl-3-(piperidine-4-yl) urea hydrochloride. The synthesis method comprises the following steps: (1) reacting N-Boc-4-aminopiperidine with methylchloroformate in a solvent in the presence of organic alkali to generate N-Boc-4-[(methoxy acyl) amino] piperidine; (2) reacting N-Boc-4-[(methoxy acyl) amino] piperidine prepared in the step (1) with methylamine in the solvent in the presence of organic alkali to generate 1-methyl-3-(N-Boc-piperidine-4-yl) urea; and (3) reacting 1-methyl-3-(N-Boc-piperidine-4-yl) urea prepared in the step (2) with acetyl chloride in the solvent to obtain a final product which is 1-methyl-3-(piperidine-4-yl) urea hydrochloride. The method is easily available in raw materials, mild in reaction condition, easy to operate and high in total yield; the molar total yield of three steps of reaction, which is metered according to the raw material N-Boc-4-aminopiperidine, can reach not less than 87%; the method is applicable to industrial production.

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes

(2S)-2-(3-Chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro (2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide (1b) has been identified as a potent CCR5 antagonist having an IC50 = 10 nM. Herein, structure-activity relationship studies of non-spiro piperidines are described, which led to the discovery of 4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidine derivatives (3-5) as potent CCR5 antagonists.