1235407-03-0

Basic information

• Product Name: 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol
• Synonyms: 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol
• CAS NO: 1235407-03-0
• Molecular Weight: 240.185
• Mol File: 1235407-03-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol(1235407-03-0)
• EPA Substance Registry System: 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol(1235407-03-0)

Safety Data

• Hazardous Substances Data: 1235407-03-0(Hazardous Substances Data)

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 463976-21-8 α,α,α-trifluoro-o-iodo-p-cresol 
• 194865-89-9 4-(tributylstannanyl)pyridazine 

Downstream Products

• 1235406-03-7 5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide 

Relevant articles and documents

A 1, 3, 4 - thiadiazole compound and its preparation method (by machine translation)

The invention discloses 2 - (5 - chloro - 2 - fluoro - 4 - (2 - (4 - pyridazinyl) - 4 - (trifluoromethyl) phenoxy) phenyl) sulfonamide - 1, 3, 4 - thiadiazole and its preparation method. 2 - (5 - chloro - 2 - fluoro - 4 - (2 - (4 - pyridazinyl) - 4 - (trifluoromethyl) phenoxy) phenyl) sulfonamide - 1, 3, 4 - thiadiazole of formula (I) structural formula shown, belonging to a new 1, 3, 4 - thiadiazole compounds, has not seen the literature reports, widens the 1, 3, 4 - thiadiazole compounds of the study area, its synthesis yield is high, simple process, and is applicable to industrial production. (by machine translation)

1,3,4-thiadiazole compound and preparation method thereof

The invention discloses 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole and a preparation method thereof. The structure of the 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole is as shown in the formula (I), and the 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole belongs to a novel 1,3,4-thiadiazole compound and is not reported in literature. The research field of 1,3,4-thiadiazole compounds is widened, the synthesis yield is high, the process is simple, and the method is suitable for industrial production.

PYRIMIDINES AS SODIUM CHANNEL BLOCKERS

The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.