463976-21-8

Basic information

• Product Name: 2-Iodo-4-(trifluoroMethyl)phenol
• Synonyms: 2-Iodo-4-(trifluoroMethyl)phenol;4-Trifluoromethyl-6-iodophenol;alpha,alpha,alpha-Trifluoro-o-iodo-p-cresol
• CAS NO: 463976-21-8
• Molecular Formula: C₇H₄F₃IO
• Molecular Weight: 288.01
• Mol File: 463976-21-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 105℃/44mm
• Appearance: /
• Refractive Index: 1.5405
• Storage Temp.: 2-8°C(protect from light)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Iodo-4-(trifluoroMethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-4-(trifluoroMethyl)phenol(463976-21-8)
• EPA Substance Registry System: 2-Iodo-4-(trifluoroMethyl)phenol(463976-21-8)

Safety Data

• Hazard Codes: 34
• Safety Statements: 20-23-26-36/37/39-45-60
• TSCA: No
• HazardClass: 8
• Hazardous Substances Data: 463976-21-8(Hazardous Substances Data)

Usage

Uses

2-Iodo-4-(trifluoromethyl)phenol is an pharmaceutical intermediate and it is an intermediate in organic synthesis.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 956219-17-3 C₁₁H₁₂F₃NO₂ 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 463976-22-9 3-methyl-5-(trifluoromethyl)benzofuran 
• 463976-23-0 6-(5-trifluoromethyl-3-methylbenzofuran-2-sulfonyl)-3-methoxypyridazine 
• 19061-34-8 1,4-epoxy-1,4-dihydro-6-(trifluoromethyl)naphthalene 
• 1235407-03-0 2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol 
• 1204817-26-4 2-phenyl-4-trifluoromethylphenol 
• 1402853-13-7 4-iodo-2-trifluoromethyldibenzofuran 
• 16238-03-2 2-phenyl-5-(trifluoromethyl)benzofuran 

Relevant articles and documents

1,3,4-thiadiazole compound and preparation method thereof

The invention discloses 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole and a preparation method thereof. The structure of the 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole is as shown in the formula (I), and the 2-(2,4-dimethoxy benzyl)-(5-chloro-2-fluoro-4-(2-(4-pyridazinyl)-4-(trifluoromethyl)phenoxy) phenyl)sulfamide-1,3,4-thiadiazole belongs to a novel 1,3,4-thiadiazole compound and is not reported in literature. The research field of 1,3,4-thiadiazole compounds is widened, the synthesis yield is high, the process is simple, and the method is suitable for industrial production.

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.7 inhibitors is described. Optimization of early lead matter focused on removal of structural alerts, improving metabolic stability and reducing cytochrome P450 inhibition driven drug-drug interaction concerns to deliver the desired balance of preclinical in vitro properties. Concerns over nonmetabolic routes of clearance, variable clearance in preclinical species, and subsequent low confidence human pharmacokinetic predictions led to the decision to conduct a human microdose study to determine clinical pharmacokinetics. The design strategies and results from preclinical PK and clinical human microdose PK data are described leading to the discovery of the first subtype selective NaV1.7 inhibitor clinical candidate PF-05089771 (34) which binds to a site in the voltage sensing domain.

BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE

The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.