16238-03-2

Basic information

• Product Name: 2-phenyl-5-(trifluoromethyl)benzofuran
• Synonyms: 2-phenyl-5-(trifluoromethyl)benzofuran
• CAS NO: 16238-03-2
• Molecular Weight: 262.231
• Mol File: 16238-03-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenyl-5-(trifluoromethyl)benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5-(trifluoromethyl)benzofuran(16238-03-2)
• EPA Substance Registry System: 2-phenyl-5-(trifluoromethyl)benzofuran(16238-03-2)

Safety Data

• Hazardous Substances Data: 16238-03-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 886496-63-5 1-bromo-2-(bromomethyl)-4-(trifluoromethyl)benzene 
• 869725-53-1 (2-bromo-5-(trifluoromethyl)phenyl)methanol 
• 1483-56-3 2-bromo-5-(trifluoromethyl)benzoic acid 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 155590-65-1 C₁₁H₁₂F₃NO₂ 
• 98-86-2 acetophenone 
• 463976-21-8 α,α,α-trifluoro-o-iodo-p-cresol 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans

An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

Copper pincer complexes as advantageous catalysts for the heteroannulation of ortho-halophenols and alkynes

A new, non-symmetrical copper(II) pincer complex catalyzes much more efficiently the formation of benzofuran by the reaction between ortho-iodophenols and alkynes. The lowest catalyst loadings are realized for this reaction, and bromo- and chlorophenols are heteroannulated for the first time. Strong evidence for hydrophenoxylation and intramolecular halogen atom-transfer steps catalyzed by this remarkably active, recyclable homogeneous catalyst is provided.