1235715-26-0

Basic information

• Product Name: 3-O-[2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamic]naltrexone
• Synonyms: 3-O-[2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamic]naltrexone
• CAS NO: 1235715-26-0
• Molecular Weight: 516.591
• Mol File: 1235715-26-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-O-[2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamic]naltrexone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-[2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamic]naltrexone(1235715-26-0)
• EPA Substance Registry System: 3-O-[2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamic]naltrexone(1235715-26-0)

Safety Data

• Hazardous Substances Data: 1235715-26-0(Hazardous Substances Data)

Upstream product

• 959215-76-0 3-O-(p-nitrophenyloxycarbonyl)naltrexone 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 

Downstream Products

• 16590-41-3 Naltrexone 

Relevant articles and documents

Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery

A small library of novel 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were synthesized. The goal behind the design of these prodrugs was to investigate their potential for microneedle-enhanced transdermal delivery. All the synthesized 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were found to have adequate stability in a transdermal formulation and improved apparent solubility compared to naltrexone. Viscosity effects were postulated to be responsible for the observed non-linearity in the flux-concentration profile of these prodrugs.