6338-55-2Relevant articles and documents
Cofactor-free detection of phosphatidylserine with cyclic peptides mimicking lactadherin
Zheng, Hong,Wang, Fang,Wang, Qin,Gao, Jianmin
, p. 15280 - 15283 (2011)
Cyclic peptides (cLacs) are designed to mimic the natural phosphatidylserine (PS) binding protein lactadherin. Unlike annexin V or its small molecule mimics, the cLac peptides selectively target PS-presenting membranes with no need for metal cofactors. We further show that a fluorophore-labeled cLac effectively stains early apoptotic cells. The small size and facile conjugation with a variety of imaging tracers make the cLac design promising for imaging cell death in vitro as well as in living organisms.
MERTK DEGRADERS AND USES THEREOF
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Paragraph 00974, (2020/01/31)
The present invention provides compounds, compositions thereof, and methods of using the same.
NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery
Xu, Huaibao,Wang, Yi,Pei, Zhichao,Ji, Wei,Pei, Yuxin
, p. 14930 - 14933 (2019/12/24)
A dual responsive NIRF turn-on protein delivery system incorporating an NIRF turn-on probe and protein into one single nanoparticle has been constructed. It can be taken up efficiently by A549 cells, where protein release and NIRF recovery happen simultaneously in response to low pH and excessive H2O2. This work provides a novel system for monitoring intracellular protein delivery.