25743-12-8 Usage
Description
NH-(PEG2-OH)2, also known as NH-bis(PEG2-OH), is a small polyethylene glycol (PEG) reagent that is commonly utilized in the field of biochemistry and pharmaceuticals. It is characterized by its ability to conjugate with carboxylic acid groups in the presence of coupling agents such as HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate) or EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide). This unique property allows NH-(PEG2-OH)2 to be a versatile building block for the creation of various bioconjugates, which can be used in a wide range of applications.
Uses
Used in Pharmaceutical Industry:
NH-(PEG2-OH)2 is used as a conjugation agent for enhancing the solubility, stability, and bioavailability of drug molecules. By attaching PEG chains to therapeutic agents, it can improve their pharmacokinetic properties, reduce immunogenicity, and prolong their circulation time in the body. This is particularly useful for the development of more effective and safer drugs.
Used in Diagnostic Industry:
In the field of diagnostics, NH-(PEG2-OH)2 is used as a labeling agent for the modification of imaging probes and contrast agents. The PEGylation of these agents can improve their stability, reduce non-specific binding, and enhance their targeting capabilities, leading to better diagnostic outcomes.
Used in Biomedical Research:
NH-(PEG2-OH)2 is employed as a versatile building block in the synthesis of various bioconjugates for research purposes. It can be used to create conjugates with a wide range of biomolecules, including peptides, proteins, nucleic acids, and small molecules, enabling the study of their interactions, properties, and functions in a controlled manner.
Used in Drug Delivery Systems:
NH-(PEG2-OH)2 is used as a component in the design and development of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The PEGylation of these systems can improve their stability, biocompatibility, and targeting capabilities, leading to more effective and safer therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 25743-12-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,7,4 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25743-12:
(7*2)+(6*5)+(5*7)+(4*4)+(3*3)+(2*1)+(1*2)=108
108 % 10 = 8
So 25743-12-8 is a valid CAS Registry Number.
25743-12-8Relevant articles and documents
Regulated assemblies and anion responsive vesicles based on 1,3-alternate oxacalix[2]arene[2]triazene amphiphiles
He, Qing,Huang, Zhi-Tang,Wang, De-Xian
supporting information, p. 12985 - 12988 (2015/02/19)
Regulated assemblies from vesicles to micelles based on 1,3-alternate oxacalix[2]arene[2]triazine amphiphilic molecules were reported. The vesicular entities were responsive to anions and followed the selectivity in the order NO3- >
INTRAMOLECULAR CYCLIZATION OF N,N-Di(OLIGOOXYETHYLENE)AMINES: A NEW SYNTHESIS OF MONOAZA CROWN ETHERS
Maeda, Hirokazu,Furuyoshi, Shigeo,Nakatsuji, Yohji,Okahara, Mitsuo
, p. 3359 - 3362 (2007/10/02)
The reaction of N,N-di(oligooxyethylene)amines with arenesulfonyl chloride in the presence of alkali metal hydroxide was investigated.It was found that the monoarenesulfonates of N,N-di(oligooxyethylene)amines were first formed as intermediates, and their subsequent intramolecular cyclization gave N-unsubstituted monoaza crown ethers rather selectively.
