33941-15-0 Usage
Description
1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, also known as 1-Aza-18-crown-6, is a cyclic compound composed of five oxygen atoms and one nitrogen atom in its structure. It is a versatile building block in organic synthesis and has potential applications in various fields.
Uses
Used in Organic Synthesis:
1,4,7,10,13-Pentaoxa-16-azacyclooctadecane is used as a building block for the synthesis of bis-crown ethers, lariat ethers, and other monofunctionalized macrocycles. Its unique structure allows for the formation of stable complexes with various metal ions, making it a valuable component in the design of new macrocyclic compounds.
Used as a Pharmaceutical Intermediate:
1,4,7,10,13-Pentaoxa-16-azacyclooctadecane is also used as a pharmaceutical intermediate. Its ability to form stable complexes with metal ions can be exploited in the development of new drugs with improved properties, such as enhanced solubility, stability, and bioavailability. Additionally, its potential applications in drug delivery systems can further enhance the therapeutic efficacy of various pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 33941-15-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,9,4 and 1 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 33941-15:
(7*3)+(6*3)+(5*9)+(4*4)+(3*1)+(2*1)+(1*5)=110
110 % 10 = 0
So 33941-15-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H25NO5/c1-3-14-5-7-16-9-11-18-12-10-17-8-6-15-4-2-13-1/h13H,1-12H2/p+1
33941-15-0Relevant articles and documents
Gokel,Garcia
, p. 317 (1977)
Aza-crown ether locked on polyethyleneimine: Solving the contradiction between transfection efficiency and safety during: In vivo gene delivery
Chen, Binggang,Jiang, Sangni,Li, Shengran,Lin, Lin,Liu, Sanrong,Ma, Xiaojing,Tian, Huayu,Wang, Wenliang,Yan, Xinxin,Yu, Xifei
, p. 5552 - 5555 (2020)
We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.
Synthesis of monoazacrown ethers under phase-transfer catalysis
Luk'yanenko,Basok,Kulygina, E. Yu.,Bogashchenko, T. Yu.,Yakovenko
, p. 1345 - 1352 (2013/02/22)
A procedure has been proposed for the synthesis of monoazacrown ethers by reaction of N-benzyldiethanolamine with oligo(ethylene glycol) bis-p-toluenesulfonates in a two-phase system aromatic hydrocarbon-50% aqueous alkali, followed by removal of the benzyl group by catalytic hydrogenolysis. The maximal yields of N-benzylaza-12-crown-4, -18-crown-6, and -21-crown-7 were achieved by adding 4-10 equiv of LiCl, BaBr2, and CsCl, respectively, to the reaction mixture, which probably indicated template effect. Pleiades Publishing, Ltd., 2012.