77544-68-4Relevant articles and documents
Phthalimide–Oxy Derivatives for 3′- or 5′-Conjugation of Oligonucleotides by Oxime Ligation and Circularization of DNA by “Bis- or Tris-Click” Oxime Ligation
Meyer, Albert,Vasseur, Jean-Jacques,Dumy, Pascal,Morvan, Fran?ois
, p. 6931 - 6941 (2017)
A solid support and two phosphoramidites exhibiting a phthalimide–oxy group were synthesized. First, after treatment with hydrazine, the resulting 5′- and 3′-oxyamine oligonucleotides were conjugated with aldehyde derivatives by oxime ligation. Second, ol
In Vitro Photodynamic Studies of a BODIPY-Based Photosensitizer
Kim, Bosung,Sui, Binglin,Yue, Xiling,Tang, Simon,Tichy, Michael G.,Belfield, Kevin D.
, p. 25 - 28 (2017)
A new halogenated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative was designed as a singlet-oxygen photosensitizer (PS) for use as a photodynamic therapy (PDT) agent, and its photophysical properties were characterized. The PS, having two i
The dynamic covalent reaction based on diselenide-containing crown ether irradiated by visible light
Shang, Jie,Gong, Hanlin,Zhang, Qian,Cui, Zhiliyu,Li, Shuangran,Lv, Ping,Pan, Tiezheng,Ge, Yan,Qi, Zhenhui
, p. 2005 - 2008 (2021)
A novel diselenide-containing crown ether (BC7Se2) was fabricated, which can polymerize to form cyclic oligomers through intermolecular dynamic covalent reaction by irradiation of visible light. The size and distribution of oligomers are relate
Mitochondrion-targeting PEGylated BODIPY dyes for near-infrared cell imaging and photodynamic therapy
Badon, Isabel Wen,Cho, Sung,Kang, Dongho,Kim, Chanwoo,Kim, Ho-Joong,Lee, Joomin,Lim, Jong Min,Mai, Duy Khuong,Vales, Temmy Pegarro,Yang, Jaesung
, p. 1196 - 1209 (2022/03/02)
A series of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-based photosensitizers (AmBXI, X = H, M, Br) featuring a cationic mitochondrion-targeting group and near-infrared (NIR) absorption was synthesized. After extending the photosensitizers' π conjugation via Knoevenagel reaction, both the absorbance and emission maxima of AmBXI shifted to the phototherapeutic wavelength range (650-900 nm). Theoretical computations indicate that the introduction of bromine atoms promotes spin-orbit coupling, so that for each additional bromine atom in AmBXI an increase in singlet oxygen quantum yield would be expected (0.3%, 2.2%, and 4.1%, for AmBHI, AmBMI, and AmBBrI, respectively). Moreover, AmBXI photosensitizers exhibited low cytotoxicity in the dark and high phototoxicity, with the half maximal inhibitory concentrations of AmBBrI found to be 46.93 nM and 22.84 nM, while those of AmBMI were 129.7 nM and 58.34 nM in HeLa and MCF-7 cancer cells, respectively. Notably, introduction of a single bromine atom was enough to produce a cytotoxic effect. Furthermore, the presence of a quaternary ammonium group in AmBXI enabled the dyes to localize and stain the negatively charged mitochondria. The results presented herein indicate the straightforward and facile synthesis of NIR-light triggered mitochondrion-targeting photosensitizers. This journal is
MODULAR CHEMICAL PROBE FOR DETECTION OF AMINO ACID CITRULLINE IN PHYSIOLOGICAL SAMPLES
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Page/Page column 16, (2021/01/29)
An improved chemical probe for the detection of the amino acid citrulline combines: 1) a reactive head formed of 1,3-dicarbonyl moiety that reacts with a citrulline side chain in an improved manner compared to currently used 1,2-dicarbonyl moieties; and 2) a modular action of the probe where citrulline side chains are labeled first using reactive heads described above, and attachment of a read-out subunit or tag, be it a fluorophore, a nanoparticle, or an antigen is performed separately. The modular nature of the chemical probe increases the sensitivity of the probes due to their smaller size. Additionally, the chemical probes of the present disclosure allow the same sample to be analyzed using a variety of read-out methods.
