124224-04-0Relevant articles and documents
Sodium percarbonate: A multifunctional reagent for the preparation of optically active 4-hydroxy-Δ2- isoxazolines
Liu, Jinchu,Eddings, Alicia,Wallace, Richard H.
, p. 6795 - 6798 (1997)
In this letter we report a general method for the preparation of optically active 4-hydroxy-Δ2-isoxazolines. This one-pot method employs sodium percarbonate for nitrile oxide generation, oxidation of the intermediate boronic ester substituted Δ2-isoxazoline, and cleavage of the chiral auxiliary from the final product.
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Shriner,Shotton,Sutherland
, p. 2794 (1938)
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Improved procedure for the synthesis of (2R)-N-propenoylbornane-2,10-sultam
Laha, Joydev K.
, p. 209 - 213 (2008)
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Influence of norbornanone substituents on both the Wagner-Meerwein skeletal rearrangements under sulfonation conditions and the diastereoselectivity of the corresponding N,N′-bis-fumaroyl sultams in uncatalyzed Diels-Alder cycloadditions to cyclopenta-1,3-diene
Pia?tek, Anna,Chapuis, Christian
, p. 4247 - 4249 (2013)
The Wagner-Meerwein domino rearrangement of norbornanone skeletons, under sulfonation conditions, is strongly influenced by the absence of a gem-dimethyl moiety at C(7). As a result, sulfonation at C(10) is less efficient due to a divergent pathway in the intermediate double bond formation and/or isomerization. Furthermore, the absence of such a gem-dimethyl moiety in the corresponding norbornane[10,2]sultam derivatives, sterically influences the orientation of the SO(1) and SO(2) substituents, hence on the π-facial steric shielding of the thermodynamically more stable anti-s-cis N-alkenoyl dienophiles. As a consequence, their diastereoselective [4+2] cycloadditions to cyclopenta-1,3-diene, under nonchelating conditions, are not as efficient due to a less pseudo axial SO(1) and the consequent loss of pseudo C 2-symmetry.
12. Complete ?-Facial Stereoselectivity in the TiCl4-Mediated Cycloaddition of Cyclopentadiene to N,N-Fumaroyldi
Chapuis, Christian,Rzepecki, Piotr,Bauer, Tomasz,Jurczak, Janusz
, p. 145 - 150 (1995)
Under the co-operative influence of two prosthetic groups, and independent of the TiCl4 concentration, complete and constant diastereofacial ?-selection was achieved during the cycloaddition of cyclopentadiene to N,N'-fumaroyl-di((-)-1c); reactive conformations are discussed.
L-(6,7-dimethoxy-4-coumaryl) alanine: An intrinsic probe for the labelling of peptides
Bennett, Fiona A.,Barlow, David J.,Dodoo, Alexander N.O.,Hider, Robert C.,Lansley, Alison B.,Lawrence, M. Jayne,Marriott, Christopher,Bansal, Sukhvinder S.
, p. 7449 - 7452 (1997)
The asymmetric synthesis, spectral properties and incorporation into solid phase peptide synthesis are described for L-(6,7-dimethoxy-4-coumaryl)alanine (Dca). Dca has great utility as a specific and highly sensitive intrinsic probe for fluorescence labelling and quantitation of peptides and proteins.
Preparation method of optically pure cyclic amino alcohol and salt thereof
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Paragraph 0086-0097, (2020/01/25)
The invention relates to the field of chemical pharmacy, particularly to a preparation method of optically pure cyclic amino alcohol and a salt thereof. The method comprises 1) hydrolysis: hydrolyzinga compound (12) to obtain a compound (13), and 2) catalytic hydrogenation: carrying out catalytic hydrogenation on the compound (13) obtained in the hydrolysis step to obtain a compound (1).
Asymmetric Electrophilic α-Amination of Silyl Enol Ether Derivatives via the Nitrosocarbonyl Hetero-ene Reaction
Sandoval, David,Samoshin, Andrey V.,Read De Alaniz, Javier
supporting information, p. 4514 - 4517 (2015/09/28)
The first example of a general asymmetric nitrosocarbonyl hetero-ene reaction is described. The procedure uses a copper-catalyzed aerobic oxidation of a commercially available chiral nitrosocarbonyl precursor (EleNOr) and is operationally simple. The tran
