125076-27-9

Basic information

• Product Name: 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• Synonyms: 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS NO: 125076-27-9
• Molecular Weight: 406.392
• Mol File: 125076-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester(125076-27-9)
• EPA Substance Registry System: 5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester(125076-27-9)

Safety Data

• Hazardous Substances Data: 125076-27-9(Hazardous Substances Data)

Upstream product

• 5891-45-2 N-benzoyloxycarbonyl D-glutamic acid α-t-benzyl ester 
• 125134-29-4 (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 125076-26-8 2-Benzyloxycarbonylamino-5-hydroxy-pentanoic acid tert-butyl ester 
• 1155-62-0 2-Benzyloxycarbonylamino-pentanedioic acid 
• 125050-12-6 tert-butyl ester of α-N-carbobenzoxy-δ-acetoxy-D-norvaline 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 125050-13-7 α-N-carbobenzoxy-δ-acetoxy-D-norvaline 

Downstream Products

• 125050-16-0 N-(benzyloxy)amide of α-N-carbobenzoxy-δ-bromo-D-norvaline 
• 125049-95-8 α-N-carbobenzoxy-δ-N-(benzyloxy)-D-cycloornithine 
• 125050-15-9 N-(benzyloxy)amide of α-N-carbobenzoxy-δ-hydroxy-D-norvaline 
• 125050-14-8 N-(benzyloxy)amide of α-N-carbobenzoxy-δ-acetoxy-D-norvaline 

Relevant articles and documents

1-Hydroxy-3-amino-2-piperidone (δ-N-Hydroxycycloornithine) Derivatives: Key Intermediates for the Synthesis of Hydroxamate-Based Siderophores

Several routes for the synthesis of δ-N-(benzyloxy)cycloornithine (2) from glutamic acid derived starting materials are described.Efficient methods were developed for the synthesis of glutamic acid γ-semialdehyde and γ-hydroxynorvaline derivatives as key substrates for the preparation of δ-N-hydroxyornithine analogues.Thus, the best approaches to the synthesis of 2 were: (1) reductive cyclization of an N-hydroxysuccinimide ester of the O-benzyloxime 4 of α-amino-protected glutamic acid γ-semialdehyde 5 and (2) cyclization of the N-(benzyloxy)amide of δ-bromonorvaline (7).