126395-29-7

Basic information

• Product Name: Carbamic acid, [(1S)-2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 126395-29-7
• Molecular Formula: C15H23NO4
• Molecular Weight: 281.352
• Mol File: 126395-29-7.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, 1,1-dimethylethyl ester(126395-29-7)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, 1,1-dimethylethyl ester(126395-29-7)

Safety Data

• Hazardous Substances Data: 126395-29-7(Hazardous Substances Data)

Upstream product

• 3417-91-2 L-tyrosine methyl ester HCl 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 17355-19-0 methyl (S)-2-amino-3-(4-methoxyphenyl)propionate 
• 7479-01-8 O-methyl-L-tyrosine methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 
• 94790-24-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate 

Downstream Products

• 120349-80-6 (Z)-(S)-4-tert-Butoxycarbonylamino-5-(4-methoxy-phenyl)-pent-2-enoic acid methyl ester 
• 120349-78-2 [(Z)-(S)-4-Hydroxy-1-(4-methoxy-benzyl)-but-2-enyl]-carbamic acid tert-butyl ester 
• 120349-79-3 (S)-tert-butyl 2-(4-methoxybenzyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 111687-94-6 (S)-2-(p-methoxyphenyl)methyl-2,5-dihydropyrrole 
• 167421-95-6 [(S)-1-Ethylsulfanylmethyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 439296-19-2 (S)-2-Azido-3-phenyl-propionic acid (S)-2-((R)-2-azido-3-phenyl-propionylamino)-3-(4-methoxy-phenyl)-propyl ester 
• 439296-20-5 [(3S,6R)-6-Benzyl-3-(4-methoxy-benzyl)-5-oxo-piperazin-(2Z)-ylidene]-acetic acid ethyl ester 
• 439296-17-0 (E)-(S)-4-((R)-2-Azido-3-phenyl-propionylamino)-5-(4-methoxy-phenyl)-pent-2-enoic acid ethyl ester 

Relevant articles and documents

New Spisulosine Derivative promotes robust autophagic response to cancer cells

Therapy resistance by evasion of apoptosis is one of the hallmarks of human cancer. Therefore, restoration of cell death by non-apoptotic mechanisms is critical to successfully overcome therapy resistance in cancer. By rational drug design approach, here we try to provide evidence that subtle changes in the chemical structure of spisulosine completely switched its cytotoxic function from apoptosis to autophagy. Our most potent molecule (26b) in a series of 16 synthesized derivatives showed robust autophagic cell death in diverse cancer cells sparing normal counterpart. Compound 26b mediated lethal autophagy induction was confirmed by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins. Altogether, we have detected novel autophagy inducer small molecule which can be tested further for drug discovery research.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.