1289430-07-4

Basic information

• Product Name: C₄₄H₈₂N₂O₁₂
• CAS NO: 1289430-07-4
• Molecular Weight: 831.141
• Mol File: 1289430-07-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₄H₈₂N₂O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₄H₈₂N₂O₁₂(1289430-07-4)
• EPA Substance Registry System: C₄₄H₈₂N₂O₁₂(1289430-07-4)

Safety Data

• Hazardous Substances Data: 1289430-07-4(Hazardous Substances Data)

Upstream product

• 76801-85-9 9-Deoxo-9a-aza-9a-homoerythromycin A 
• 2043-61-0 cyclohexanecarbaldehyde 
• 111321-02-9 erythromycin A 9-(E)-oxime 
• 114-07-8 erythromycin 
• 227948-37-0 C₄₄H₇₄N₂O₁₅S 

Relevant articles and documents

Chemistry and biology of macrolide antiparasitic agents

Macrolide antibacterial agents inhibit parasite proliferation by targeting the apicoplast ribosome. Motivated by the long-term goal of identifying antiparasitic macrolides that lack antibacterial activity, we have systematically analyzed the structure-activity relationships among erythromycin analogues and have also investigated the mechanism of action of selected compounds. Two lead compounds, N-benzylazithromycin (11) and N-phenylpropylazithromycin (30), were identified with significantly higher antiparasitic activity and lower antibacterial activity than erythromycin or azithromycin. Molecular modeling based on the cocrystal structure of azithromycin bound to the bacterial ribosome suggested that a substituent at the N-9 position of desmethylazithromycin could improve selectivity because of species-specific interactions with the ribosomal L22 protein. Like other macrolides, these lead compounds display a strong "delayed death phenotype"; however, their early effects on T. gondii replication are more pronounced.