76801-85-9Relevant articles and documents
Method for synthesizing azorithromycin by utilizing erythromycin thiocyanate oxime
-
Paragraph 0037; 0041-0043; 0044; 0048-0051; 0055-0057, (2021/05/05)
The invention relates to a method for synthesizing azithromycin by utilizing erythromycin thiocyanate oxime. The method comprises the following process steps: removing thiocyanate radicals through erythromycin thiocyanate oxime dissociation, performing rearrangement reaction, performing continuous back extraction, performing continuous reduction reaction and separation, and performing azithromycin crystallizing. According to the invention, the thiocyanate radicals are removed before the rearrangement reaction and then the rearrangement is performed, the reduction reaction adopts a continuous reaction process, the reaction mode is changed, and the process is high in reaction efficiency, low in production cost, small in environmental pollution, high in product yield and good in product quality.
Novel crystal-form compound of dihydroerythromycin and preparation method thereof
-
Paragraph 0026-0031, (2019/02/13)
The invention relates to a novel crystal-form compound of dihydroerythromycin and a preparation method thereof, and belongs to the technical field of synthesis of heterocyclic compounds. Erythromycinimide ether is dissolved in methanol, a catalyst Pt/C is added after acid adjustment, and a hydrogenation reaction is performed; after the reaction is finished, the catalyst is filtered, and a set amount of methanol is recovered; the temperature is dropped and the alkalinity is adjusted to the pH value of 10-12, a set amount of water is added drop by drop, and the novel crystal-form compound of dihydroerythromycin is obtained by filtration and drying. The preparation method is applied in synthesis of dihydroerythromycin and has the advantages of good fluidity, easy packaging, high liquid content and the like.
Synthesis method of azithromycin
-
Paragraph 0003; 0025-0026, (2017/08/29)
The invention relates to a synthesis method of azithromycin. The synthesis method is characterized by comprising the process steps of firstly adding sodium bicarbonate and a rearrangement reaction reagent to erythromycin oxime in a reaction system employing water as a reaction solvent for rearrangement reaction, carrying out heat preservation for 2-3 hours, dropwise adding a reduction reaction regent for reduction reaction and stirring for 1-2 hours during heat preservation; adding a competitive inhibitor for removing boron through reduction hydrolysis for reduction and boron removal reaction; and finally separating out crystal, and cooling and filtering to obtain the azithromycin. Rearrangement and reduction are simultaneously carried out in the same reaction system. Compared with a sodium borohydride reduction method in the prior art, the synthesis method has the advantages that the process is simplified, use of an organic solvent and the like is omitted, the environmental pollution and the product cost are reduced, the influence of a complicated process on the quality of a product is reduced, the quality and the yield of the product are finally improved and the synthesis method is suitable for technological production.