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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Azaerythromycin supplier in China

Cas:76801-85-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

DD-Azaerythromycin A manufacturer/supplier

Cas:76801-85-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Azathramycin A Cas 76801-85-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:cool dry place Package:25kg/drum Application:

Manufacturer high quality Azathramycin A Cas 76801-85-9 with good price

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience 2. Free samples will be provided,ensure specifications and quality are right for customer 3. Customers will receive the most professional techn

High Quality 99% Azithromycin Amine 76801-85-9 GMP manufacturer

Cas:76801-85-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Azathramycin in stock

Cas:76801-85-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

10-Dihydro-10-deoxo-11-azaethrythromycin A

Cas:76801-85-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Azathramycin

Cas:76801-85-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Azathramycin

Cas:76801-85-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Azathramycin/ LIDE PHARMA- Factory supply / Best price

Cas:76801-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name Azithromycin Amine CAS Number 76801-85-9 Molecular Formula C37H70N2O12 Molecular Weight

Azathramycin CAS: 76801-85-9

Cas:76801-85-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Azathramycin

Cas:76801-85-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in China

Azathramycin cas 76801-85-9

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Azathramycin Structure: Formula: C37H70N2O12 Molecular Weight : 734.96 Synonyms: AzithromycinEPImpurityA/(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4

Factory Supply High Quality Azathramycin

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Azathramycin CAS: 76801-85-9 MF: C37H70N2O12 MW: 734.96 EINECS: 616-385-9 Mol File: 76801-85-9.mol Azathramycin Structure Azathramycin Chemical Properties Melting point 126-136°C Boiling point 815.2&plusm

Azathramycin

Cas:76801-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Azathramycin CAS:76801-85-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Azathramycin CAS:76801-85-9

Cas:76801-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:76801-85-9

Cas:76801-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Azathramycin CAS: 76801-85-9 Specification Items Specification Result Appearance White or almost white powder White powder Purity ≥

Factory supply Azathramycin

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Azathramycin

Cas:76801-85-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

AZITHROMYCIN INTEMEDIATES

Cas:76801-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zhejiang Huili Pharmaceutical Co., Ltd

ProName: Azathramycin A CAS: 76801-85-9 CasNo: 76801-85-9 Molecular Formula: C37H70N2O12 Appearance: powder Application: Pharmaceutical intermediates DeliveryTime: 7-10 working days after deposit PackAge: Inside plastic outside Port: Tianjin

Azithromycin amine

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

10-Dihydro-10-deoxo-11-azaethrythromycin A

Cas:76801-85-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Azaerythromycin

Cas:76801-85-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Novel intermediate of Azithromycin that acts as antibiotic

AAzathramycin

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Azathramycin

Cas:76801-85-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Azathramycin Basic information Product Name: Azathramycin Synonyms: DESMETHYL AZITHROMYCIN;AZAERYTHROMYCIN A (100 MG) (9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A);9-Deoxo

TIANFU-CHEM Azathramycin 76801-85-9

Cas:76801-85-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Azathramycin (Azaerythromycin A

Cas:76801-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-homoerythromycin A
342371-84-0

9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-homoerythromycin A

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With potassium borohydride In methanol at 0 - 5℃; for 2h;93%
Stage #1: 9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-homoerythromycin A With hydrogen; acetic acid; platinum(IV) oxide In methanol at 40 - 45℃; pH=5 - 6;
Stage #2: With sodium hydroxide In water pH=11 - 12;
85%
Stage #1: 9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-homoerythromycin A With sodium tetrahydroborate; acetic acid pH=6 - 8; Heating;
Stage #2: With gluconic acid at 8℃; Reagent/catalyst; Temperature;
84.4%
With sodium tetrahydroborate In methanol at 0 - 25℃; Inert atmosphere;77%
With methanol; sodium tetrahydroborate at 0 - 20℃; for 24h;70.3%
C37H66N2O12

C37H66N2O12

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: C37H66N2O12 With perchloric acid; hydrogen; platinum on activated charcoal In methanol at 5 - 42℃; under 10298 Torr; for 3h; pH=5.5;
Stage #2: With sodium hydroxide In water pH=12 - 12.5;
91.5%
C37H66N2O12

C37H66N2O12

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: C37H66N2O12 With perchloric acid; hydrogen; platinum on activated charcoal In methanol; water at 5 - 42℃; under 10298 Torr; for 3h; pH=5.5;
Stage #2: With sodium hydroxide In water pH=12 - 12.5; Product distribution / selectivity;
86.6%
C37H66N2O12

C37H66N2O12

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: C37H66N2O12 With potassium borohydride; acetic acid In water at 14℃; under 22502.3 Torr; pH=7; Flow reactor;
Stage #2: In ethyl acetate
Stage #3: With hydrogenchloride In water; ethyl acetate for 0.05h; Pressure; Temperature; pH-value; Solvent;
86%
(9-E)-deoxo-9-hydroximinoerythromycin A
13127-18-9

(9-E)-deoxo-9-hydroximinoerythromycin A

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: (9-E)-deoxo-9-hydroximinoerythromycin A With calcium(II) bis(trifluoromethanesulfonyl)imide; tert-butylammonium hexafluorophosphate(V) In 1,2-dimethoxyethane; 1,2-dichloro-ethane at 80℃; for 5h;
Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 51h;
78%
Multi-step reaction with 2 steps
1: p-toluenesulfonyl chloride; sodium hydrogencarbonate / acetone; water / 4 h / 0 - 20 °C
2: sodium tetrahydroborate; methanol / 24 h / 0 - 20 °C
View Scheme
erythromycin A 9-(E)-oxime
111321-02-9

erythromycin A 9-(E)-oxime

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Rearrangement; Beckmann-like rearrangement; reduction;45%
Stage #1: erythromycin A 9-(E)-oxime With sodium hydrogencarbonate; p-toluenesulfonyl chloride In acetone Beckmann rearrangement;
Stage #2: With hydrogen; platinum on activated charcoal In methanol under 30003 Torr; for 12h; Further stages.;
Multi-step reaction with 2 steps
1: methanol; water / 5 h / 5 °C / Inert atmosphere
2: sodium tetrahydroborate / methanol / 4 - 20 °C / Inert atmosphere
View Scheme
erythromycin 6,9-imino ether

erythromycin 6,9-imino ether

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With platinum on carbon; hydrogen In methanol at 40 - 45℃; under 7500.75 Torr; for 4h; Autoclave;17.1%
C70H128BN4O26(1-)*Na(1+)

C70H128BN4O26(1-)*Na(1+)

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With Amberlite IRA-743; sulfuric acid; water for 0.5h; pH=2.8;
C38H70N2O12
944124-75-8

C38H70N2O12

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: C38H70N2O12 With sodium tetrahydroborate; formic acid In water at 0 - 20℃; for 11h; pH=6 - 8;
Stage #2: With malic acid In water
Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;
C44H74N2O15S
227948-37-0

C44H74N2O15S

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 4 - 20℃; Beckmann rearrangement; Inert atmosphere;300 mg
erythromycin
114-07-8

erythromycin

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine; acetic acid / water; isopropyl alcohol / 15 h / 50 °C / Inert atmosphere
2: methanol; water / 5 h / 5 °C / Inert atmosphere
3: sodium tetrahydroborate / methanol / 4 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; triethylamine / methanol / 24 h / Reflux
2: p-toluenesulfonyl chloride; sodium hydrogencarbonate / acetone; water / 4 h / 0 - 20 °C
3: sodium tetrahydroborate; methanol / 24 h / 0 - 20 °C
View Scheme
erythromycin A oxime thiocyanate
1357466-70-6

erythromycin A oxime thiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: erythromycin A oxime thiocyanate With sodium hydroxide In dichloromethane at 10℃; pH=9 - 11;
Stage #2: With sodium tetrahydroborate In dichloromethane at 10℃; pH=0.5 - 2.5;
57.4 g
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate; p-toluenesulfonyl chloride / acetone / 4 h / 0 - 10 °C
2.1: phosphoric acid; potassium borohydride / water / 8 h / 0 - 5 °C / pH 7 - 9
2.2: 3 h / 0 - 5 °C / pH 2.5 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / dichloromethane; water / 38 °C
2.1: sodium carbonate; p-toluenesulfonyl chloride / water / 3.2 h / 12 °C / pH Ca. 7
3.1: acetic acid; potassium borohydride / water / 14 °C / 22502.3 Torr / pH 7 / Flow reactor
3.3: 0.05 h
View Scheme
erythromycin A thiocyanate
7704-67-8

erythromycin A thiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; triethylamine / methanol / 52 h / 30 - 55 °C / pH 6.3 - 6.7
2.1: sodium hydrogencarbonate; p-toluenesulfonyl chloride / acetone / 4 h / 0 - 10 °C
3.1: phosphoric acid; potassium borohydride / water / 8 h / 0 - 5 °C / pH 7 - 9
3.2: 3 h / 0 - 5 °C / pH 2.5 - 3
View Scheme
erythromycin A 6,9-imino ether

erythromycin A 6,9-imino ether

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: erythromycin A 6,9-imino ether With potassium borohydride; phosphoric acid In water at 0 - 5℃; for 8h; pH=7 - 9;
Stage #2: With hydrogenchloride In dichloromethane; water at 0 - 5℃; for 3h; pH=2.5 - 3; Reagent/catalyst;
benzyl chloroformate
501-53-1

benzyl chloroformate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-2-O-[(phenylmethoxy)carbonyl]-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
352032-78-1

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-2-O-[(phenylmethoxy)carbonyl]-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Conditions
ConditionsYield
In dichloromethane at 0℃;100%
Stage #1: benzyl chloroformate; 9-Deoxo-9a-aza-9a-homoerythromycin A In dichloromethane at -10 - 3℃; for 0.166667h;
Stage #2: With triethylamine In dichloromethane at 3℃; for 2h;
96.9%
In dichloromethane at 0 - 5℃; for 1h;84.57%
acrylonitrile
107-13-1

acrylonitrile

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9-deoxo-9a-aza-9a-(β-cyanoethyl)-9a-homoerythromycin A
92627-70-8

9-deoxo-9a-aza-9a-(β-cyanoethyl)-9a-homoerythromycin A

Conditions
ConditionsYield
at 80℃; for 24h; Michael addition;99%
at 60℃; for 16h; Inert atmosphere;63%
for 7h; Heating / reflux;41%
formaldehyd
50-00-0

formaldehyd

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With formic acid In acetone at 30 - 55℃; for 4h;95%
Stage #1: formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A With formic acid In acetone at 40 - 45℃; for 7 - 8h;
Stage #2: With sodium hydroxide In water; acetone pH=11 - 11.5;
87%
With formic acid In water; ethyl acetate for 2h; Heating / reflux;77%
9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9-deoxo-9-dihydro-3'-N-oxide-9a-aza-9a-homoerythromycin A

9-deoxo-9-dihydro-3'-N-oxide-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With dihydrogen peroxide In methanol; water at 0 - 20℃; for 2h;94.3%
With dihydrogen peroxide In methanol; water at 0 - 20℃; for 2h;94.3%
Benzyl isothiocyanate
622-78-6

Benzyl isothiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C45H77N3O12S
166036-09-5

C45H77N3O12S

Conditions
ConditionsYield
With triethylamine In acetonitrile at 60℃; for 3h;92%
phenyl chloroformate
1885-14-9

phenyl chloroformate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C44H74N2O14

C44H74N2O14

Conditions
ConditionsYield
In dichloromethane at -5 - 0℃; for 3h;92%
formaldehyd
50-00-0

formaldehyd

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

azithromycin dihydrate

azithromycin dihydrate

Conditions
ConditionsYield
Stage #1: formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A With formic acid In acetone at 40 - 45℃; for 7 - 8h;
Stage #2: With sodium hydroxide In water; acetone pH=11 - 11.5;
Stage #3: With water In acetone at 20℃; for 24h;
87%
Stage #1: formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A With formic acid In water; acetone at 20 - 55℃; for 8h;
Stage #2: With water In acetone at 38 - 40℃; for 10 - 12h;
Stage #3: With water
76.7%
Stage #1: formaldehyd; 9-Deoxo-9a-aza-9a-homoerythromycin A With formic acid In chloroform; water at 20 - 55℃; for 10 - 20h; Heating / reflux;
Stage #2: With water In acetone at 38 - 40℃; for 10 - 12h;
73%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-2-O-(tert-butoxycarbonyl)-β-D-xylo-hexopyranosyl)oxy)-1-oxa-6-(tert-butoxycarbonyl)azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-2-O-(tert-butoxycarbonyl)-β-D-xylo-hexopyranosyl)oxy)-1-oxa-6-(tert-butoxycarbonyl)azacyclopentadecan-15-one

Conditions
ConditionsYield
With dmap In tetrahydrofuran at -5 - 5℃; for 10.5h; Solvent; Reflux;86.3%
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9-deoxo-9a-aza-9a-(γ-hydroxypropyl)-9a-homoerythromycin A
96779-85-0

9-deoxo-9a-aza-9a-(γ-hydroxypropyl)-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: acrylic acid methyl ester; 9-Deoxo-9a-aza-9a-homoerythromycin A at 60℃; for 30h; Addition; hetero-Michael addition;
Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h; Reduction;
84%
9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

3-O-decladinosyl-9-deoxo-9a-aza-9a-homoerythromycin A
111247-94-0

3-O-decladinosyl-9-deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 24h; pH=1;79%
Stage #1: 9-Deoxo-9a-aza-9a-homoerythromycin A With formaldehyd; formic acid In water for 30h; Reflux;
Stage #2: With sodium hydroxide In water pH=11;
61%
With hydrogenchloride at 20℃; for 12h;
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

3-(9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A) propionic acid methyl ester
955955-02-9

3-(9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A) propionic acid methyl ester

Conditions
ConditionsYield
In chloroform at 60℃; for 48h;65%
In chloroform at 60℃; for 48h; Heating / reflux;53.7%
9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10,11,13-pentahydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-15-one
111247-95-1

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10,11,13-pentahydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-15-one

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃; for 10h;60.1%
With hydrogenchloride In water at 60℃; for 64h;
imidazole-1-carboxylic acid [2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-amide
287727-89-3

imidazole-1-carboxylic acid [2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-amide

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9a-aza-9a-[(3'-deoxythymidin-3'-yl)aminocarbonyl]-9-deoxo-9a-homoerythromycin A

9a-aza-9a-[(3'-deoxythymidin-3'-yl)aminocarbonyl]-9-deoxo-9a-homoerythromycin A

Conditions
ConditionsYield
Stage #1: imidazole-1-carboxylic acid [2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-amide; 9-Deoxo-9a-aza-9a-homoerythromycin A In N,N-dimethyl-formamide; acetonitrile at 50℃; for 2h; Acylation;
Stage #2: With pyridine; hydrogen fluoride In tetrahydrofuran at 0℃; Decomposition;
50%
(11-carboxyundecyl)triphenylphosphonium bromide
7530-96-3

(11-carboxyundecyl)triphenylphosphonium bromide

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

{11-[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-6-yl]-11-oxoundecyl}triphenylphosphonium chloride

{11-[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-azacyclopentadecan-6-yl]-11-oxoundecyl}triphenylphosphonium chloride

Conditions
ConditionsYield
Stage #1: (11-carboxyundecyl)triphenylphosphonium bromide With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide In dichloromethane at 40℃; for 0.5h;
Stage #2: 9-Deoxo-9a-aza-9a-homoerythromycin A In dichloromethane at 40℃;
Stage #3: In methanol
49%
Stage #1: (11-carboxyundecyl)triphenylphosphonium bromide With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide In dichloromethane at 40℃; for 0.5h;
Stage #2: 9-Deoxo-9a-aza-9a-homoerythromycin A In dichloromethane at 40℃;
Stage #3: In methanol
0.4 g
ethyl isocyanate
109-90-0

ethyl isocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C40H75N3O13
1289429-77-1

C40H75N3O13

Conditions
ConditionsYield
In toluene at 20℃; for 1h; Inert atmosphere;47%
3-methoxybiphenyl-4-yl isothiocyanate
1304028-65-6

3-methoxybiphenyl-4-yl isothiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9a,11-O-{N'-[4-(3-methoxy)biphenyl]carbonimidoyl}-9-deoxo-9a-aza-9a-homoerythromycin A

9a,11-O-{N'-[4-(3-methoxy)biphenyl]carbonimidoyl}-9-deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With triethylamine In acetonitrile at 60℃;41%
isopropyl isothiocyanate
2253-73-8

isopropyl isothiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

9a,11-O-(N'-isopropropylcarbonimidoyl)-9-deoxo-9a-aza-9a-homoerythromycin A

9a,11-O-(N'-isopropropylcarbonimidoyl)-9-deoxo-9a-aza-9a-homoerythromycin A

Conditions
ConditionsYield
With triethylamine In acetonitrile at 60℃;39%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C45H77N3O13
166036-08-4

C45H77N3O13

Conditions
ConditionsYield
In toluene Inert atmosphere;35%
Allyl acetate
591-87-7

Allyl acetate

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C40H74N2O12
119471-59-9

C40H74N2O12

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); triethylamine at 20 - 80℃; for 22h; Inert atmosphere;26%
propionaldehyde
123-38-6

propionaldehyde

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

n-propyl azithromycin
92594-48-4

n-propyl azithromycin

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In N,N-dimethyl-formamide at 70℃; for 7h; Inert atmosphere;24%
With 5%-palladium/activated carbon; hydrogen In ethanol at 35 - 45℃; under 750.075 - 4500.45 Torr; for 4h; Temperature; Pressure; Solvent; Reagent/catalyst; Autoclave;
benzaldehyde
100-52-7

benzaldehyde

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

C44H76N2O12
119471-61-3

C44H76N2O12

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In N,N-dimethyl-formamide Inert atmosphere;21%
9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

C44H82N2O12
1289430-07-4

C44H82N2O12

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In N,N-dimethyl-formamide Inert atmosphere;21%
4-Ethynylbenzaldehyde
63697-96-1

4-Ethynylbenzaldehyde

9-Deoxo-9a-aza-9a-homoerythromycin A
76801-85-9

9-Deoxo-9a-aza-9a-homoerythromycin A

(N10-(4-ethynylbenzyl))azithromycin

(N10-(4-ethynylbenzyl))azithromycin

Conditions
ConditionsYield
Stage #1: 4-Ethynylbenzaldehyde; 9-Deoxo-9a-aza-9a-homoerythromycin A With acetic acid In N,N-dimethyl-formamide for 0.5h;
Stage #2: With sodium cyanoborohydride In N,N-dimethyl-formamide at 70℃; for 7h;
20%

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