It conforms to USP.We have GMP for this mterial. Appearance:White crystalline powder Storage:room temperature Package:25kg/drum or customer requirements Application:medicine additives , functional food additives,cosmetic additives etc. Transportati
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:114-07-8
Min.Order:1 Kilogram
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Type:Trading Company
inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------
Cas:114-07-8
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryWe are an independent, privately owned company comprised of a dedicated team of professionals with a singular purpose: your success. To us, you are not a project and you’re not only a client. You are our strategic partner. We know our success
Unique advantages for Erythromycin Cas 114-07-8 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:0-6°C Package:1kg/foil bag, 25kg/dru
Cas:114-07-8
Min.Order:1 Kilogram
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inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:114-07-8
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryErythromycin CAS No.:114-07-8 Name: Erythromycin Synonyms: (-)-Erythromycin Molecular Structure Molecular Formula: C37H67NO13 Molecular Weight: 733.93
Cas:114-07-8
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:114-07-8
Min.Order:1 Gram
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inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. As a leading manufacturer and supplier of chemicals in China, Day
Cas:114-07-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryName:Erythromycin CAS NO: 114-07-8 Grade:Medical scientific research and export Molecular formula:C37H67NO13 Molecular weight: 733.93 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat
Cas:114-07-8
Min.Order:25 Kilogram
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Type:Other
inquiryErythromycin Basic information Product Name: Erythromycin Synonyms: abboticin;abomacetin;dotycin;em;emu;e-mycin;erycin;erycinum CAS: 114-07-8 MF:
Cas:114-07-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:114-07-8
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:114-07-8
Min.Order:25 Kilogram
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Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:114-07-8
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inquiryName: Erythromycin Synonyms: Abomacetin CAS:114-07-8 MF: C37H67NO13 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:APIs Transportation:By sea or by air Port:Qingdao port
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & d
Cas:114-07-8
Min.Order:100 Gram
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Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:114-07-8
Min.Order:1 Kilogram
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:114-07-8
Min.Order:10 Gram
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Type:Trading Company
inquiryErythromycin is white or almost white crystalline or powder;Odorless, bitter taste; slight moist.In methanol, ethanol or acetone soluble,Very slightly soluble in water. Erythromycin can affect the protein synthesis, general bacteria to gram-
Cas:114-07-8
Min.Order:1 Kilogram
FOB Price: $140.0 / 150.0
Type:Trading Company
inquiryErythromycin CAS:114-07-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:114-07-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:114-07-8
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,
Cas:114-07-8
Min.Order:1 Kilogram
FOB Price: $70.0 / 100.0
Type:Trading Company
inquiryEP Standard API CAS: 114-07-8 Specificatio Items Specification Result Assay 93.0% ~102.0% 98.0% Appearance
1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 40℃; pH=9-9.8; | 99.33% |
With ammonia In dichloromethane; water at 25 - 35℃; | |
In dichloromethane; water at 37℃; pH=12; Product distribution / selectivity; | |
With ammonia In water at 35 - 70℃; for 1.5h; Reagent/catalyst; | 106 g |
Conditions | Yield |
---|---|
With hydrogen; Raney-Ni (W4) In ethanol at 25℃; for 1h; | 84% |
With hydrogen; Rany Ni (W4) In ethanol at 25℃; for 1h; | 84% |
(2',4''-O-bistrimethylsilyl)-6-O-methylerythromycinA-9[O-(1-ethoxy-1-methylethyl)]oxime
erythromycin
Conditions | Yield |
---|---|
With formic acid; water; sodium hydrogensulfite In ethanol for 8h; Heating; | 66.7% |
Conditions | Yield |
---|---|
With sodium cyanoborohydride In methanol; water for 0.5h; Ambient temperature; | A 11.4% B n/a |
Conditions | Yield |
---|---|
In methanol; water for 0.5h; Ambient temperature; | A 11.4% B n/a |
9-deoxo-9-iminoerythromycin A
erythromycin
Conditions | Yield |
---|---|
With water at 5℃; Yield given; | |
With water In methanol at 23℃; pH 7, methanol-phosphate buffer, various pH, other erythromycin; | |
With hydrogenchloride; water In ethanol pH=5 - 6; |
9-N,11-O-benzylidene-9-deoxo-9-iminoerythromycin A
erythromycin
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; pH 7 (1:1 methanol-phosphate buffer); |
C45H74N2O12
erythromycin
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; pH 7 (1:1 methanol-phosphate buffer); |
C44H71ClN2O12
erythromycin
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; pH 7 (1:1 methanol-phosphate buffer); |
C45H74N2O13
erythromycin
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; pH 7 (1:1 methanol-phosphate buffer); |
C44H71N3O14
erythromycin
Conditions | Yield |
---|---|
With water at 37℃; Rate constant; pH 7 (1:1 methanol-phosphate buffer); |
erythromycin A 9-(E)-oxime
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 30 percent / Bu3P / tetrahydrofuran / 1 h / 0 °C 2: H2O; HCl / ethanol / pH 5 - 6 View Scheme | |
Multi-step reaction with 2 steps 1.1: PySeSePy; Me3P / tetrahydrofuran / 0.17 h / 0 °C 1.2: 80 percent / H2O / pH 10 2.1: H2O; HCl / ethanol / pH 5 - 6 View Scheme |
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Bu3P / tetrahydrofuran / 1 h / 0 °C 2: H2O; HCl / ethanol / pH 5 - 6 View Scheme |
9S-Dihydroerythronolide A aglycon
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 87 percent / DL-10-camphorsulfonic acid / CH2Cl2 / 72 h / -30 °C 2: 100 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1.5 h / 25 °C 3: 95 percent / H2 / Pd(OH)2/C / ethyl acetate / 2 h / 25 °C 4: 63 percent / silver triflate, 4A molecular sieves / CH2Cl2; toluene / 4 h / 25 °C 5: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 6: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 7: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 8: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 9: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 10: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 11: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 11 steps 1: 87 percent / CSA / CH2Cl2 / 72 h / -30 °C 2: PPTS / CH2Cl2 / 1.5 h / 25 °C 3: H2 / Pd(OH)2 / 2 h / 25 °C 4: 63 percent / AgOTf, MS 4A / CH2Cl2; toluene / 4 h / 0 - 25 °C 5: 99 percent / mCPBA / CHCl3 / 0.33 h / 25 °C 6: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 7: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 8: 54 percent / H2 / Raney-Ni (W4) / ethanol 9: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 10: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 11: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydro-9,11-O-isopropylideneerythronolide A
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 63 percent / silver triflate, 4A molecular sieves / CH2Cl2; toluene / 4 h / 25 °C 2: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 3: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 4: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 5: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 6: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 7: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 8: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 8 steps 1: 63 percent / AgOTf, MS 4A / CH2Cl2; toluene / 4 h / 0 - 25 °C 2: 99 percent / mCPBA / CHCl3 / 0.33 h / 25 °C 3: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 4: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 5: 54 percent / H2 / Raney-Ni (W4) / ethanol 6: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 7: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 8: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydro-3,5-O-(p-methoxybenzylidene)erythronolide A
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 100 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1.5 h / 25 °C 2: 95 percent / H2 / Pd(OH)2/C / ethyl acetate / 2 h / 25 °C 3: 63 percent / silver triflate, 4A molecular sieves / CH2Cl2; toluene / 4 h / 25 °C 4: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 5: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 6: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 7: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 8: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 9: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 10: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 10 steps 1: PPTS / CH2Cl2 / 1.5 h / 25 °C 2: H2 / Pd(OH)2 / 2 h / 25 °C 3: 63 percent / AgOTf, MS 4A / CH2Cl2; toluene / 4 h / 0 - 25 °C 4: 99 percent / mCPBA / CHCl3 / 0.33 h / 25 °C 5: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 6: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 7: 54 percent / H2 / Raney-Ni (W4) / ethanol 8: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 9: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 10: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydro-9,11-O-isopropylidene-3,5-O-(p-methoxybenzylidene)erythronolide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 95 percent / H2 / Pd(OH)2/C / ethyl acetate / 2 h / 25 °C 2: 63 percent / silver triflate, 4A molecular sieves / CH2Cl2; toluene / 4 h / 25 °C 3: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 4: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 5: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 6: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 7: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 8: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 9: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 9 steps 1: H2 / Pd(OH)2 / 2 h / 25 °C 2: 63 percent / AgOTf, MS 4A / CH2Cl2; toluene / 4 h / 0 - 25 °C 3: 99 percent / mCPBA / CHCl3 / 0.33 h / 25 °C 4: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 5: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 6: 54 percent / H2 / Raney-Ni (W4) / ethanol 7: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 8: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 9: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydro-9,11-O-isopropylidene-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 2: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 3: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 4: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 5: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 6: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 7: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 7 steps 1: 99 percent / mCPBA / CHCl3 / 0.33 h / 25 °C 2: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 3: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 4: 54 percent / H2 / Raney-Ni (W4) / ethanol 5: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 6: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 7: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydro-9,11-O-isopropylidene-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide A N-oxide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 2: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 3: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 4: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 5: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 6: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 6 steps 1: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 2: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 3: 54 percent / H2 / Raney-Ni (W4) / ethanol 4: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 5: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 6: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydroerythromycin A N-oxide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 2: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 2: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-3-O-(2,6-anhydro-4-O-benzyl-3-C-methyl-3-O-methyl-2-thio-α-L-altropyranosyl)-9-dihydro-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide A N-Oxide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 2: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 3: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 4: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1: 54 percent / H2 / Raney-Ni (W4) / ethanol 2: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 3: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 4: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-3-O-(2,6-anhydro-4-O-benzyl-3-C-methyl-3-O-methyl-2-thio-α-L-altropyranosyl)-9-dihydro-9,11-O-isopropylidene-5-O-(2-O-(methoxycarbonyl)-β-D-desosaminyl)erythronolide A N-Oxide
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 2: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 3: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 4: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 5: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 5 steps 1: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 2: 54 percent / H2 / Raney-Ni (W4) / ethanol 3: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 4: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 5: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
methyl 2,6-anhydro-4-O-benzyl-3-C-methyl-3-O-methyl-2-thio-α-L-altropyranoside
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 91 percent / TMSOTf / CH2Cl2 / 0.25 h / 0 °C 2: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 3: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 4: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 5: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 6: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 7: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 7 steps 1: 96 percent / TMSOTf / CH2Cl2 / 0.17 h / -10 °C 2: 90 percent / NIS, TfOH, MS 4A / CH2Cl2 / 0.17 h / -35 °C 3: 66 percent / 50percent aq. AcOH / 24 h / 40 °C 4: 54 percent / H2 / Raney-Ni (W4) / ethanol 5: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 6: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 7: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
phenyl 2,6-anhydro-4-O-benzyl-3-C-methyl-3-O-methyl-1,2-dithio-β-L-altro-pyranoside
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 2: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 3: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 4: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 5: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 6: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
1-(2-pyrimidinethio) 3,4,6-trideoxy-2-O-methoxycarbonyl-3-(dimethylamino)-D-xylo-hexopyranoside
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 63 percent / silver triflate, 4A molecular sieves / CH2Cl2; toluene / 4 h / 25 °C 2: 100 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.25 h / 25 °C 3: 90 percent / 4A molecular sieves, N-iodosuccinimide, TfOH / CH2Cl2 / 0.17 h / -35 °C 4: 66 percent / 50percent aq. AcOH / 12 h / 40 °C 5: 54 percent / H2 / Raney Ni (W4) / ethanol / 1.5 h / 40 °C 6: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 7: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 8: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
(9S)-9-dihydroerythromycin A
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.17 h / 25 °C 2: 58 percent / bis(tri-n-butyltin) oxide, Br2 / CH2Cl2 / 24 h / 25 °C 3: 84 percent / H2 / Rany Ni (W4) / ethanol / 1 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: 99 percent / mCPBA / CHCl3 / 0.17 h / 25 °C 2: 58 percent / (n-Bu3Sn)2O, Br2 / CH2Cl2 / 24 h / 25 °C 3: 84 percent / H2 / Raney-Ni (W4) / ethanol / 1 h / 25 °C View Scheme |
D-desosamine
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: (NCO2Et)2, P(n-Bu)3 / toluene / -30 - 25 °C 2: aq. NaHCO3 / CH2Cl2 / 25 °C 3: silver triflate / CH2Cl2; toluene / 25 °C 4: Pb(ClO4)2 / acetonitrile / 25 °C 5: MeOH 6: 75 percent / Na-Hg/MeOH 7: N-chlorosuccinimide / pyridine / 25 °C 8: AgF / hexamethylphosphoric acid triamide / 70 °C 9: H2O / 5 °C View Scheme |
4-acetyl-L-cladinose
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 72 percent / P(n-Bu)3 / CH2Cl2 / 0 °C 2: Pb(ClO4)2 / acetonitrile / 25 °C 3: MeOH 4: 75 percent / Na-Hg/MeOH 5: N-chlorosuccinimide / pyridine / 25 °C 6: AgF / hexamethylphosphoric acid triamide / 70 °C 7: H2O / 5 °C View Scheme |
erythromycylamine
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-chlorosuccinimide / pyridine / 25 °C 2: AgF / hexamethylphosphoric acid triamide / 70 °C 3: H2O / 5 °C View Scheme |
4-O-acetyl-1-deoxy-1-(2-pyridylthio)-α-L-cladinoside
erythromycin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Pb(ClO4)2 / acetonitrile / 25 °C 2: MeOH 3: 75 percent / Na-Hg/MeOH 4: N-chlorosuccinimide / pyridine / 25 °C 5: AgF / hexamethylphosphoric acid triamide / 70 °C 6: H2O / 5 °C View Scheme |
succinic acid anhydride
erythromycin
2'-O-(3-carboxypropanoyl) erythromycin
Conditions | Yield |
---|---|
In acetone at 50℃; | 100% |
With acetone | |
With dichloromethane |
erythromycin
erythromycin A 9-(E)-oxime
Conditions | Yield |
---|---|
With hydroxylamine; acetic acid In water; isopropyl alcohol at 50℃; for 15h; Inert atmosphere; | 100% |
With hydroxylamine hydrochloride; sodium acetate; acetic acid In methanol at 55℃; for 24h; | 98% |
With hydroxylamine hydrochloride; triethylamine In methanol for 96h; Heating / reflux; | 84% |
erythromycin
lactobionic acid
erythromycin lactobionate
Conditions | Yield |
---|---|
With water at 5 - 40℃; Product distribution / selectivity; | 99% |
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol; water at 15 - 20℃; for 20h; | 98% |
With dihydrogen peroxide In methanol; water at 20℃; for 19h; | 90% |
With dihydrogen peroxide In methanol at 20℃; | 88% |
With sodium periodate; ethanol; water | |
With dihydrogen peroxide |
erythromycin
(9-E)-deoxo-9-hydroximinoerythromycin A
Conditions | Yield |
---|---|
With hydroxylamine; acetic acid In isopropyl alcohol at 50℃; for 24h; | 95% |
With hydroxylamine hydrochloride; triethylamine In methanol Reflux; | 93% |
With hydroxylamine hydrochloride; potassium carbonate In methanol at 20℃; for 48h; Solvent; Reagent/catalyst; Temperature; | 88.2% |
2-Methoxypropene
erythromycin
11,12-isopropylidene-8,9-anhydroerythromycin A 6,9-hemiacetal
Conditions | Yield |
---|---|
With pyridine hydrochloride In chloroform for 24h; Ambient temperature; | 94% |
ethanol
erythromycin
(2S,3S,4R,6S)-6-Ethoxy-4-methoxy-2,4-dimethyl-tetrahydro-pyran-3-ol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetonitrile for 1h; Ambient temperature; | 92% |
Conditions | Yield |
---|---|
With pyridine In ethyl acetate at 20℃; for 1h; | 91% |
In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; | 66% |
In dichloromethane at 20℃; | |
With 1-methyl-1H-imidazole | |
In dichloromethane |
erythromycin
(9S)-9-dihydroerythromycin A
Conditions | Yield |
---|---|
Stage #1: erythromycin With sodium tetrahydroborate In diethyl ether; isopropyl alcohol at 0 - 20℃; for 3h; Stage #2: With triethanolamine In diethyl ether; water; isopropyl alcohol for 2h; pH=6.5; Product distribution / selectivity; | 86% |
With sodium tetrahydroborate In diethyl ether; isopropyl alcohol at 0 - 20℃; | 86% |
With aluminum oxide; sodium tetrahydroborate | 82% |
Conditions | Yield |
---|---|
Stage #1: erythromycin In acetone at 35℃; pH=8.5; Stage #2: sodium thiocyanide In acetone Concentration; pH-value; Temperature; Solvent; | 85.1% |
Stage #1: erythromycin With LACTIC ACID; water at 5 - 40℃; Stage #2: sodium thiocyanide In water at -15 - 10℃; Product distribution / selectivity; | |
Stage #1: erythromycin In acetone at 35℃; pH=8.5; Stage #2: sodium thiocyanide In acetone | 85.1 %Chromat. |
Conditions | Yield |
---|---|
With sodium hydroxide; iodine; sodium acetate In methanol; water at 20 - 50℃; for 3.5h; pH=8 - 9; | 84% |
With iodine; sodium acetate In methanol; water | 34% |
With sodium hydroxide; iodine; sodium acetate In methanol; water for 2.5h; |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2h; | 84% |
erythromycin
Conditions | Yield |
---|---|
With hydrogenchloride at 20℃; pH=1.7; | 81% |
prop-2-yn-1-ol methanesulfonate
tert-butyl 2-azidoacetate
erythromycin
CH3O3S(1-)*C46H81N4O15(1+)
Conditions | Yield |
---|---|
80% |
benzyl chloroformate
erythromycin
B
2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A
Conditions | Yield |
---|---|
With sodium hydrogencarbonate at 50℃; for 1h; | A n/a B 79% |
C21H36O4
erythromycin
A
2'-O-linoleoylerythromycin A
B
4''-O-linoleoylerythromycin A
C
erythromycin, 2'-(ethyl carbonate)
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 20℃; for 10h; | A 78% B n/a C 5% |
benzyl chloroformate
erythromycin
2'-O,3'-N-bis(benzyloxycarbonyl)-N-demethylerythromycin A
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In toluene | 77% |
With sodium hydrogencarbonate |
chloro-trimethyl-silane
erythromycin
2',4''-O-Bis(trimethylsilyl)erythromycin A
Conditions | Yield |
---|---|
With 1-(Trimethylsilyl)imidazole In ethyl acetate for 0.5h; Ambient temperature; | 76% |
erythromycin
phenylcarbonochloridothioate
erythromycin A-2'-phenylthionoformate
Conditions | Yield |
---|---|
With 1,2,2,6,6-pentamethylpiperidine; 1-methyl-1H-imidazole In dichloromethane at 20℃; for 2h; | 76% |
With triethylamine |
methanesulfonyl chloride
erythromycin
2',4''-di-O-methanesulfonylerythromycin A
Conditions | Yield |
---|---|
With triethylamine In acetone 1.) 0 to 3 deg C, 30 min, 2.) RT, 2 h; | 75.7% |
erythromycin
Conditions | Yield |
---|---|
With glycosyltransferase OleD; Tris buffer at 37℃; pH=7.8; | 74% |
Conditions | Yield |
---|---|
With C47H62N8O10; triethylamine In chloroform Inert atmosphere; | A 71% B n/a |
With pyridine Title compound not separated from byproducts.; |
erythromycin
EM 201
Conditions | Yield |
---|---|
With acetic acid at 20℃; for 2h; | 71% |
Product distribution / selectivity; Acidic aqueous solution; |
Conditions | Yield |
---|---|
With pyridine at 25℃; for 72h; | A 70% B n/a |
erythromycin
8,9-anhydroerythromycin A 6,9-hemiacetal
Conditions | Yield |
---|---|
With acetic acid for 1h; Ambient temperature; | 68% |
With acetic acid Erwaermen bei vermindertem Druck; | |
With acetic acid at 20℃; | |
With acetic acid at 20℃; for 0.75h; |
erythromycin
3-tert-butoxycarbonylamino-propionic acid anhydride
C
C53H93N3O19
Conditions | Yield |
---|---|
With C47H62N8O10; triethylamine In chloroform at 20℃; for 65h; Inert atmosphere; | A 13% B 3% C 68% |
erythromycin
3-tert-butoxycarbonylamino-propionic acid anhydride
B
C53H93N3O19
Conditions | Yield |
---|---|
With C47H62N8O10; triethylamine In chloroform Inert atmosphere; | A n/a B 68% |
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