1289626-08-9

Basic information

• Product Name: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid
• Synonyms: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid
• CAS NO: 1289626-08-9
• Molecular Weight: 335.219
• Mol File: 1289626-08-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid(1289626-08-9)
• EPA Substance Registry System: 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid(1289626-08-9)

Safety Data

• Hazardous Substances Data: 1289626-08-9(Hazardous Substances Data)

Upstream product

• 1289626-07-8 ethyl 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoate 
• 4654-39-1 4-bromophenethanol 
• 85356-68-9 1-bromo-4-(2-iodoethyl)benzene 

Downstream Products

• 1289626-34-1 (2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (-)-ephedrine 
• 1289626-32-9 (2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid 
• 1289620-95-6 (+/-)-4-(4-bromophenyl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide 
• 1289626-83-0 (+/-)-2-methyl-2-(methylsulfonyl)-4-(4'-nitrobiphenyl-4-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1289626-09-0 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 

Relevant articles and documents

Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents

LpxC inhibitors are new-type antibacterial agents developed in the last twenty years, mainly against Gram-negative bacteria infections. To develop novel LpxC inhibitors with good antibacterial activities and biological metabolism, we summarized the basic skeleton of reported LpxC inhibitors, designed and synthesized several series of compounds and tested their antibacterial activities against Escherichial coli and Pseudomonas aeruginosa in vitro. Structure-activity relationships have been discussed in this article. The metabolism stability of YDL-2, YDL-5, YDL-8, YDL-14, YDL-20–YDL-23 have been evaluated in liver microsomes, which indicated that the 2-amino isopropyl group may be a preferred structure than the 2-hydroxy ethyl group in the design of LpxC inhibitors.